ArticleScientific reports2019
Multidimensional diffusion MRI with spectrally modulated gradients reveals unprecedented microstructural detail.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
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Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Considerations and recommendations from the ISMRM diffusion study group for preclinical diffusion MRI: Part 2-Ex vivo imaging: Added value and acquisition.Magnetic resonance in medicine · 2025Guideline
- Human In Vivo Validation of Frequency-Dependent QTI.Magnetic resonance in medicine · 2026Article
- Restriction-Weighted Q-Space Trajectory Imaging (ResQ): Toward Mapping Diffusion-Time Effects With Tensor-Valued Diffusion Encoding in Human Prostate Cancer Xenografts.NMR in biomedicine · 2026Article
- Evaluation of the diffusion time dependence of the IVIM effect based on realistic capillary flow simulations in mouse brain.Magma (New York, N.Y.) · 2026Article
- Frequency-Dependent Diffusion-Relaxation Distribution MRI: Scan-Rescan Reproducibility Ex Vivo and Caveats.NMR in biomedicine · 2026Article
- Analysis of cortical dysplasias using b-tensor encoding diffusion MRI in an animal model.PloS one · 2026Article
- Data-driven classification of tissue water populations by massively multidimensional diffusion-relaxation correlation MRI.Frontiers in neuroscience · 2026Article
- Mapping structures and dynamics with frequency-correlated diffusion exchange.Science advances · 2025Article
- Validity of the Gaussian phase distribution approximation for analysis of isotropic diffusion encoding applied to restricted diffusion in a cylinder.Magnetic resonance letters · 2025Article
- Considerations and recommendations from the ISMRM diffusion study group for preclinical diffusion MRI: Part 1: In vivo small-animal imaging.Magnetic resonance in medicine · 2025Review
- Ex vivo massively multidimensional diffusion-relaxation correlation MRI: scan-rescan reproducibility and caveats.bioRxiv : the preprint server for biology · 2025Article
- Assessing tumor microstructure with time-dependent diffusion imaging: Considerations and feasibility on clinical MRI and MRI-Linac.Medical physics · 2025Article
- Frequency-dependence in multidimensional diffusion-relaxation correlation MRI of the brain: Overfitting or meaningful parameter?Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Spectral principal axis system (SPAS) and tuning of tensor-valued encoding for microscopic anisotropy and time-dependent diffusion in the rat brain.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- In vivo rat brain mapping of multiple gray matter water populations using nonparametric D(ω)-RNMR in biomedicine · 2025Article
- Tuned exchange imaging: Can the filter exchange imaging pulse sequence be adapted for applications with thin slices and restricted diffusion?NMR in biomedicine · 2024Article
- Pore size estimation in axon-mimicking microfibers with diffusion-relaxation MRI.Magnetic resonance in medicine · 2024Article
- Article
- Cardiac q-space trajectory imaging by motion-compensated tensor-valued diffusion encoding in human heart in vivo.Magnetic resonance in medicine · 2023Article
- Multidimensional encoding of restricted and anisotropic diffusion by double rotation of theMagnetic resonance (Gottingen, Germany) · 2023Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Characterization of porous media is essential in a wide range of biomedical and industrial applications. Microstructural features can be probed non-invasively by diffusion magnetic resonance imaging (dMRI). However, diffusion encoding in conventional dMRI may yield similar signatures for very different microstructures, which represents a significant limitation for disentangling individual microstructural features in heterogeneous materials. To solve this problem, we propose an augmented multidimensional diffusion encoding (MDE) framework, which unlocks a novel encoding dimension to assess time-dependent diffusion specific to structures with different microscopic anisotropies. Our approach relies on spectral analysis of complex but experimentally efficient MDE waveforms. Two independent contrasts to differentiate features such as cell shape and size can be generated directly by signal subtraction from only three types of measurements. Analytical calculations and simulations support our experimental observations. Proof-of-concept experiments were applied on samples with known and distinctly different microstructures. We further demonstrate substantially different contrasts in different tissue types of a post mortem brain. Our simultaneous assessment of restriction size and shape may be instrumental in studies of a wide range of porous materials, enable new insights into the microstructure of biological tissues or be of great value in diagnostics.
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Registered trials
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