ArticleScientific reports2019
Chromatin Compaction by Small RNAs and the Nuclear RNAi Machinery in C. elegans.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 30 citations in OpenAlex.
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- The functions and modifications of tRNA-derived small RNAs in cancer biology.Cancer metastasis reviews · 2025Review
- Multiplex DNA fluorescence in situ hybridization to analyze maternal vs. paternal C. elegans chromosomes.Genome biology · 2024Article
- Sensitized piRNA reporter identifies multiple RNA processing factors involved in piRNA-mediated gene silencing.Genetics · 2023Article
- The origin of RNA interference: Adaptive or neutral evolution?PLoS biology · 2022Article
- Dual roles for nuclear RNAi Argonautes in Caenorhabditis elegans dosage compensation.Genetics · 2022Article
- SETDB1-like MET-2 promotes transcriptional silencing and development independently of its H3K9me-associated catalytic activity.Nature structural & molecular biology · 2022Article
- DAF-18/PTEN inhibits germline zygotic gene activation during primordial germ cell quiescence.PLoS genetics · 2021Article
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- Small RNAs and chromatin in the multigenerational epigenetic landscape ofPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- tRNA-Derived Small RNAs: Novel Epigenetic Regulators.Cancers · 2020Review
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- DICER regulates the expression of major satellite repeat transcripts and meiotic chromosome segregation during spermatogenesis.Nucleic acids research · 2020Article
- Emerging Roles for Chromo Domain Proteins in Genome Organization and Cell Fate inFrontiers in cell and developmental biology · 2020Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
DNA is organized and compacted into higher-order structures in order to fit within nuclei and to facilitate gene regulation. Mechanisms by which higher order chromatin structures are established and maintained are poorly understood. In C. elegans, nuclear-localized small RNAs engage the nuclear RNAi machinery to regulate gene expression and direct the post-translational modification of histone proteins. Here we confirm a recent report suggesting that nuclear small RNAs initiate or maintain chromatin compaction states in C. elegans germ cells. Additionally, we show that experimentally provided small RNAs are sufficient to direct chromatin compaction and that this compaction requires the small RNA-binding Argonaute NRDE-3, the pre-mRNA associated factor NRDE-2, and the HP1-like protein HPL-2. Our results show that small RNAs, acting via the nuclear RNAi machinery and an HP1-like protein, are capable of driving chromatin compaction in C. elegans.
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