Evidence map›Paper›PMID 31227581›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2019

Critical Roles for Coiled-Coil Dimers of Butyrophilin 3A1 in the Sensing of Prenyl Pyrophosphates by Human Vγ2Vδ2 T Cells.

Hong Wang, Mohanad H Nada, Yoshimasa Tanaka, Shun Sakuraba, Craig T Morita

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Cell stress activates γ9δ2 T cells via endogenous phosphoantigens and butyrophilin complex dynamics.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Investigation of structural and dynamic properties of the Butyrophilin BTN3A1/BTN2A1 cytoplasmic complex byFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Alpaca (Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Hong WangDivision of Immunology, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242.
Mohanad H NadaDivision of Immunology, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242.ORCID 0000-0002-1993-2495
Yoshimasa TanakaCenter for Bioinformatics and Molecular Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523, Japan.ORCID 0000-0002-5024-0614
Shun SakurabaGraduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba 277-8561, Japan; and.ORCID 0000-0001-5768-2389
Craig T MoritaDivision of Immunology, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242; Craig-Morita@uiowa.edu.ORCID 0000-0001-8496-8294
University of Iowa · USHyogo Medical University · JPThe University of Tokyo · JP

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0M
Metabolic Engineering of Bacteria for Cancer Immunotherapy by Gamma Delta T CellsI01BX000972 · VA · IOWA CITY VA MEDICAL CENTER · PI MORITA, CRAIG T · 2012 to 2023
–
BLRD VA I01 BX000972NCI NIH HHS P30 CA086862
6 · The paper itself

Abstract

Vγ2Vδ2 T cells play important roles in human immunity to pathogens and tumors. Their TCRs respond to the sensing of isoprenoid metabolites, such as (

Indexed as

Amino Acid SequenceAmino Acid SubstitutionAntigens, CDB30.2-SPRY DomainButyrophilinsCD8-Positive T-LymphocytesDimerizationHemiterpenesHumansLymphocyte ActivationMolecular Dynamics SimulationOrganophosphatesOrganophosphorus CompoundsReceptors, Antigen, T-Cell, gamma-delta4-hydroxy-3-methyl-2-butenyl diphosphateAntigens, CDBTN3A1 protein, humanButyrophilinsHemiterpenesisopentenyl pyrophosphateOrganophosphatesOrganophosphorus CompoundsReceptors, Antigen, T-Cell, gamma-delta

Identifiers

PMID31227581
PMCPMC6834341
OpenAlexW2949290496

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.