ArticleThe Journal of experimental medicine2019
Single-cell transcriptomic analysis of tissue-resident memory T cells in human lung cancer.
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In one paragraph
Article in The Journal of experimental medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 175 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
175citing papers in PubMed, 2 pooled it
12.5field-weighted citation impact, top 1% of its field
What it found
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Who cites it
175 citing papers in PubMed, 2 syntheses or guidelines pooled it, 251 citations in OpenAlex.
- A comprehensive meta-analysis of tissue resident memory T cells and their roles in shaping immune microenvironment and patient prognosis in non-small cell lung cancer.Frontiers in immunology · 2024Pooled it
- A Systematic Review on PD-1 Blockade and PD-1 Gene-Editing of CAR-T Cells for Glioma Therapy: From Deciphering to Personalized Medicine.Frontiers in immunology · 2021Pooled it
- Perioperative pembrolizumab in early-stage non-small cell lung cancer (NSCLC): conventional and distribution-based immune profiling of the tumor microenvironment and peripheral circulation.Journal for immunotherapy of cancer · 2025Trial
- Distinct CD8Cancer cell · 2025Trial
- Continuous replenishment of the dysfunctional CD8 T cell axis is associated with response to chemoimmunotherapy in advanced breast cancer.Cell reports. Medicine · 2025Trial
- Oncolytic adenovirus in treating malignant ascites: A phase II trial and longitudinal single-cell study.Molecular therapy : the journal of the American Society of Gene Therapy · 2024Trial
- Article
- Distinct migratory dendritic cell subsets cooperate to prime tissue-resident memory-like CD8⁺ T cells in mouse tumors.Nature communications · 2026Article
- Clonal sharing and plasticity of follicular CD4 + T cells across lymph nodes and tumors in non-small cell lung cancer.Nature communications · 2026Article
- TSTScope Unifies Single-Cell Multi-Omics to Identify Functional T Cell States Predictive of Immunotherapy Response.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Human lungs maintain tissue-resident memory T cells against a broad spectrum of pathogens.Nature immunology · 2026Article
- The initial melanoma T cell infiltrate is defined by tissue-resident programs restrained by regulatory T cells.Research square · 2026Article
- CD8MedComm · 2026Review
- GZMK expression within activated intratumoral T-cell subsets reflects differentiation efficiency and predicts response to cancer immunotherapy.NPJ precision oncology · 2026Article
- The Evolution of Spatial Omics Technologies Introduces A Novel Avenue for Lung Cancer Research.Genomics, proteomics & bioinformatics · 2026Review
- The Proximity of PD-1Cancers · 2026Article
- CD103-Positive Tumor-Infiltrating Lymphocytes Predict a Favorable Prognosis in Colorectal Cancer with Liver Metastasis.Annals of surgical oncology · 2026Article
- Comparative analysis of malignant pleural effusion and peripheral blood reveals unique T cell signatures associated with survival in mesothelioma patients.Oxford open immunology · 2026Article
- Antigen reactivity defines tissue-resident memory and exhausted T cells in tumors.Nature immunology · 2026Article
- CD8Frontiers in immunology · 2026Review
115 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 4 institutions in 2 countries.
James ClarkeLa Jolla Institute for Immunology, La Jolla, CA.
Bharat PanwarLa Jolla Institute for Immunology, La Jolla, CA.
Ariel MadrigalLa Jolla Institute for Immunology, La Jolla, CA.
Divya SinghLa Jolla Institute for Immunology, La Jolla, CA.
Ravindra GujarLa Jolla Institute for Immunology, La Jolla, CA.
Oliver WoodNational Institute for Health Research and Cancer Research UK Southampton Experimental Cancer Medicine Center, National Institute for Health Research Southampton Biomedical Research Center, Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, UK.
Serena J CheeNational Institute for Health Research and Cancer Research UK Southampton Experimental Cancer Medicine Center, National Institute for Health Research Southampton Biomedical Research Center, Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, UK.
Simon EschweilerLa Jolla Institute for Immunology, La Jolla, CA.
Emma V KingNational Institute for Health Research and Cancer Research UK Southampton Experimental Cancer Medicine Center, National Institute for Health Research Southampton Biomedical Research Center, Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, UK.
Amiera S AwadSouthampton University Hospitals National Health Service Foundation Trust, Southampton, UK.
Christopher J HanleyNational Institute for Health Research and Cancer Research UK Southampton Experimental Cancer Medicine Center, National Institute for Health Research Southampton Biomedical Research Center, Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, UK.ORCID 0000-0003-3816-7220
Katy J McCannNational Institute for Health Research and Cancer Research UK Southampton Experimental Cancer Medicine Center, National Institute for Health Research Southampton Biomedical Research Center, Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, UK.
Sourya BhattacharyyaLa Jolla Institute for Immunology, La Jolla, CA.
Edwin WooSouthampton University Hospitals National Health Service Foundation Trust, Southampton, UK.
Aiman AlzetaniSouthampton University Hospitals National Health Service Foundation Trust, Southampton, UK.
Grégory SeumoisLa Jolla Institute for Immunology, La Jolla, CA.ORCID 0000-0002-8164-6852
Gareth J ThomasNational Institute for Health Research and Cancer Research UK Southampton Experimental Cancer Medicine Center, National Institute for Health Research Southampton Biomedical Research Center, Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, UK.
Anusha-Preethi GanesanLa Jolla Institute for Immunology, La Jolla, CA.
Peter S FriedmannClinical and Experimental Sciences, National Institute for Health Research Southampton, Respiratory Biomedical Research Unit, University of Southampton, Faculty of Medicine, Southampton, UK.
Tilman Sanchez-ElsnerClinical and Experimental Sciences, National Institute for Health Research Southampton, Respiratory Biomedical Research Unit, University of Southampton, Faculty of Medicine, Southampton, UK.ORCID 0000-0003-1915-2410
Ferhat AyLa Jolla Institute for Immunology, La Jolla, CA.ORCID 0000-0002-0708-6914
Christian H Ottensmeier *National Institute for Health Research and Cancer Research UK Southampton Experimental Cancer Medicine Center, National Institute for Health Research Southampton Biomedical Research Center, Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, UK C.H.Ottensmeier@soton.ac.uk.ORCID 0000-0003-3619-1657
Pandurangan Vijayanand *La Jolla Institute for Immunology, La Jolla, CA vijay@lji.org.ORCID 0000-0001-7067-9723
La Jolla Institute for Immunology · USCancer Research UK · GBNational Health Service · GBNational Institute for Health Research · GB
Funding
NovaSeq5000 High Throughput SequencerS10OD025052 · OD · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI SEUMOIS, GREGORY · 2018 to 2018
$832kIllumina HiSeq 2500 Sequencing SystemS10OD016262 · OD · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI RAO, ANJANA · 2013 to 2013
$600kFACSAria II Cell SorterS10RR027366 · NCRR · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI CROFT, MICHAEL · 2011 to 2011
$514kCancer Research UK 21998NCRR NIH HHS S10 RR027366NIH HHS S10 OD016262NIH HHS S10 OD025052
Abstract
High numbers of tissue-resident memory T (T
Indexed as
Gene Expression ProfilingSingle-Cell AnalysisCell ProliferationClone CellsCytotoxicity, ImmunologicHepatitis A Virus Cellular Receptor 2HumansImmunologic MemoryLungLung NeoplasmsLymphocytes, Tumor-InfiltratingLymphocyte SubsetsProgrammed Cell Death 1 ReceptorRNA, MessengerT-LymphocytesTranscription, GeneticHAVCR2 protein, humanHepatitis A Virus Cellular Receptor 2PDCD1 protein, humanProgrammed Cell Death 1 ReceptorRNA, Messenger
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.