Evidence map›Paper›PMID 31227523›Full record

ArticleThe Journal of biological chemistry2019

High-throughput screening for phosphatidylserine decarboxylase inhibitors using a distyrylbenzene-bis-aldehyde (DSB-3)-based fluorescence assay.

Adam Hendricson, Sheila Umlauf, Jae-Yeon Choi, Jose Thekkiniath, Yulia V Surovtseva, Kevin K Fuller, Todd B Reynolds, Dennis R Voelker, Choukri Ben Mamoun

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. WIPI4 loss linked to ferroptosis.Nature cell biology · 2024
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Adam HendricsonYale Center for Molecular Discovery, West Haven, Connecticut 06516.
Sheila UmlaufYale Center for Molecular Discovery, West Haven, Connecticut 06516.
Jae-Yeon ChoiBasic Science Section, Department of Medicine, National Jewish Health, Denver, Colorado 80206.
Jose ThekkiniathDepartment of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, Connecticut 06520.
Yulia V SurovtsevaYale Center for Molecular Discovery, West Haven, Connecticut 06516.
Kevin K FullerDepartments of Ophthalmology and Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104.
Todd B ReynoldsDepartment of Microbiology, College of Arts and Sciences, University of Tennessee, Knoxville, Tennessee 37996.
Dennis R VoelkerBasic Science Section, Department of Medicine, National Jewish Health, Denver, Colorado 80206.
Choukri Ben MamounDepartment of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, Connecticut 06520. Electronic address: choukri.benmamoun@yale.edu.
University of Colorado Denver · USYale University · USKnoxville College · USUniversity of Oklahoma Health Sciences Center · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Development of endochin-like quinolones for babesiosis therapyR01AI123321 · NIAID · YALE UNIVERSITY · PI BEN MAMOUN, CHOUKRI · 2017 to 2020
$2.7M
An antigen-detection assay to diagnose Babesia microti infectionR44AI136118 · NIAID · L2 DIAGNOSTICS, LLC · PI LEDIZET, MICHEL · 2020 to 2022
$2.1M
Function and Inhibition of Plasmodium Lipid DecarboxylasesR01AI097218 · NIAID · YALE UNIVERSITY · PI BEN MAMOUN, CHOUKRI · 2012 to 2016
$2.0M
Synthesis and Study of Complex Antiproliferative and Antimalarial Natural ProductsR01GM110506 · NIGMS · YALE UNIVERSITY · PI HERZON, SETH B. · 2015 to 2018
$1.2M
Structure and Function of Eukaryotic Phosphatidylserine DecarboxylaseR01GM104485 · NIGMS · NATIONAL JEWISH HEALTH · PI VOELKER, DENNIS R. · 2013 to 2016
$1.2M
An antigen-detection assay to diagnose Babesia microti infectionR43AI136118 · NIAID · L2 DIAGNOSTICS, LLC · PI LEDIZET, MICHEL · 2018 to 2018
$300k
NCATS NIH HHS UL1 TR001863NIAID NIH HHS R01 AI097218NIAID NIH HHS R01 AI123321NIAID NIH HHS R43 AI136118NIAID NIH HHS R44 AI136118NIGMS NIH HHS R01 GM104485NIGMS NIH HHS R01 GM110506
6 · The paper itself

Abstract

Phosphatidylserine decarboxylases (PSDs) catalyze the decarboxylation of phosphatidylserine to generate phosphatidylethanolamine, a critical step in phospholipid metabolism in both prokaryotes and eukaryotes. Most PSDs are membrane-bound, and classical radioisotope-based assays for determining their activity

Indexed as

High-Throughput Screening AssaysCandida albicansCarboxy-LyasesCell Line, TumorCell SurvivalEnzyme InhibitorsEthanolamineFluorescent DyesHumansInhibitory Concentration 50PhosphatidylserinesPlasmodium knowlesiRecombinant ProteinsStyrenesCarboxy-LyasesdistyrylbenzeneEnzyme InhibitorsEthanolamineFluorescent Dyesphosphatidylserine decarboxylasePhosphatidylserinesRecombinant ProteinsStyrenesantimicrobial agentCandida albicansenzymehigh-throughput screening (HTS)parasitic diseasephosphatidylethanolaminephosphatidylserinephosphatidylserine decarboxylasephospholipidsplasmodiumPlasmodium falciparumPlasmodium knowlesi

Identifiers

PMID31227523
PMCPMC6690695
OpenAlexW2952116869

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.