Evidence map›Paper›PMID 31227476›Full record

ArticleBlood advances2019

Inhibition of EZH2 and immune signaling exerts synergistic antitumor effects in chronic lymphocytic leukemia.

Elisavet Chartomatsidou, Stavroula Ntoufa, Konstantia Kotta, Alessandra Rovida, Maria Anna Akritidou, Daniela Belloni, Elisabetta Ferrero, Theoni Trangas, Niki Stavroyianni, Achilles Anagnostopoulos and 4 more

Open access · goldAbstract readComparative Study
In one paragraph

Article in Blood advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. TLR9: A Double-Dealing Toll-Like Receptor.ImmunoTargets and therapy · 2025
    Review
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  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Elisavet ChartomatsidouInstitute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, Greece.
Stavroula NtoufaInstitute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, Greece.
Konstantia KottaInstitute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, Greece.
Alessandra RovidaStrategic Research Program on CLL and B-cell Neoplasia Unit, Division of Experimental Oncology, Università Vita-Salute San Raffaele and IRCCS Istituto Scientifico San Raffaele, Milan, Italy.
Maria Anna AkritidouInstitute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, Greece.
Daniela BelloniStrategic Research Program on CLL and B-cell Neoplasia Unit, Division of Experimental Oncology, Università Vita-Salute San Raffaele and IRCCS Istituto Scientifico San Raffaele, Milan, Italy.
Elisabetta FerreroStrategic Research Program on CLL and B-cell Neoplasia Unit, Division of Experimental Oncology, Università Vita-Salute San Raffaele and IRCCS Istituto Scientifico San Raffaele, Milan, Italy.
Theoni TrangasDepartment of Biological Applications and Technology, University of Ioannina, Ioannina, Greece.
Niki StavroyianniDepartment of Hematology-BMT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece.
Achilles AnagnostopoulosDepartment of Hematology-BMT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece.
Richard RosenquistDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; and.
Paolo GhiaStrategic Research Program on CLL and B-cell Neoplasia Unit, Division of Experimental Oncology, Università Vita-Salute San Raffaele and IRCCS Istituto Scientifico San Raffaele, Milan, Italy.ORCID 0000-0003-3750-7342
Nikos PapakonstantinouInstitute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, Greece.
Kostas StamatopoulosInstitute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, Greece.
Centre for Research and Technology Hellas · GRVita-Salute San Raffaele University · ITUniversity of Ioannina · GRG. Papanikolaou General Hospital · GRUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdenineAntineoplastic AgentsAntineoplastic Combined Chemotherapy ProtocolsApoptosisB-LymphocytesBridged Bicyclo Compounds, HeterocyclicDown-RegulationDrug SynergismEnhancer of Zeste Homolog 2 ProteinEnzyme InhibitorsHistonesHumansIndazolesIndolesLeukemia, Lymphocytic, Chronic, B-CellPiperidinesAdenineAntineoplastic AgentsBridged Bicyclo Compounds, HeterocyclicEnhancer of Zeste Homolog 2 ProteinEnzyme InhibitorsEZH2 protein, humanGSK-2816126GSK343HistonesibrutinibidelalisibIndazolesIndolesPiperidinesPurinesPyrazolesPyridonesPyrimidinesQuinazolinonesSulfonamidesvenetoclax

Identifiers

PMID31227476
PMCPMC6595263
OpenAlexW2949805106

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.