ArticleCell host & microbe2019
Pathogenic Autoreactive T and B Cells Cross-React with Mimotopes Expressed by a Common Human Gut Commensal to Trigger Autoimmunity.
2 registry-linked trialsOpen access · bronzeAbstract read
In one paragraph
Article in Cell host & microbe, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 84 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 1 pooled it
14.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Longitudinal Study of the Fecal Microbiome in Persistently Anti-β2 Glycoprotein-I Positive Individuals and Patients With Antiphospholipid Syndrome
The Human Microbiome in Immune-Mediated Diseases
Who cites it
84 citing papers in PubMed, 1 synthesis or guideline pooled it, 149 citations in OpenAlex.
- The role of the intestinal microbiome in antiphospholipid syndrome.Frontiers in immunology · 2022Pooled it
- Antigen-specific activation of gut immune cells drives autoimmune neuroinflammation.Gut microbes · 2026Article
- Distinct vaginal microbial signatures in pregnancies complicated by antiphospholipid syndrome: depletion ofMicrobiology spectrum · 2026Article
- The Gut Microbiota: Emerging Evidence in Autoimmune and Inflammatory Diseases.Research (Washington, D.C.) · 2026Review
- Cross-Reactivity of Antiphospholipid Antibodies with Gut Commensal Proteins in Antiphospholipid Syndrome.TH open : companion journal to thrombosis and haemostasis · 2026Article
- Autoimmune disease-associated pathobionts: mechanisms and therapeutic potential of phage-based approaches.Frontiers in immunology · 2026Review
- The role of neutrophil extracellular traps in antiphospholipid syndrome.Frontiers in immunology · 2026Review
- Beyond celiac disease: the potential role of gluten in Hashimoto's thyroiditis.Frontiers in endocrinology · 2026Review
- Infant Viability in Severe Preeclampsia: Management Strategies and the Potential Role of Calprotectin-A Narrative Review.Children (Basel, Switzerland) · 2025Review
- Pharmacological insights into gut microbiota modulation in systemic lupus erythematosus: Mechanisms, treatment strategies, and clinical implications.The Journal of pharmacology and experimental therapeutics · 2025Review
- IgG4 elevation dilemma at the crossroads of helminth infection and IgG4-related disease: insights from a case report of pediatric paragonimiasis with persistent pericardial effusion.Translational pediatrics · 2025Article
- B Cell Tolerance and Obstetric Antiphospholipid Syndrome.Clinical reviews in allergy & immunology · 2025Review
- Molecular mimicry in the pathogenesis of autoimmune rheumatic diseases.Journal of translational autoimmunity · 2025Review
- Article
- The Complex Role of Gut Microbiota in Systemic Lupus Erythematosus and Lupus Nephritis: From Pathogenetic Factor to Therapeutic Target.Microorganisms · 2025Review
- Human microbiome-derived peptide affects the development of experimental autoimmune encephalomyelitis via molecular mimicry.EBioMedicine · 2025Article
- Novel advances on pathophysiological mechanisms, clinical manifestations, and treatment of antiphospholipid syndrome.Frontiers in immunology · 2025Review
- Phosphatidylcholine-specific B cells are enriched among atypical CD11cFrontiers in immunology · 2025Article
- Interacting roles of gut microbiota and T cells in the development of autoimmune hepatitis.Frontiers in immunology · 2025Review
- Mechanism of antiphospholipid antibody-mediated thrombosis in antiphospholipid syndrome.Frontiers in immunology · 2025Review
24 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 2 countries.
William E RuffDepartment of Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.
Carina DehnerDepartment of Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.
Woo J KimDepartment of Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.
Odelya PagovichDepartment of Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.
Cassyanne L AguiarBarbara Volcker Center for Women and Rheumatic Diseases, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY 10021, USA.
Andrew T YuDepartment of Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.
Alexander S RothDepartment of Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.
Silvio Manfredo VieiraDepartment of Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.
Christina KriegelDepartment of Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.
Olamide AdeniyiDepartment of Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.
Melissa J MullaDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, CT 06510, USA.
Vikki M AbrahamsDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, CT 06510, USA.
William W KwokBenaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA.
Ruth NussinovComputational Structural Biology Section, Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA; Sackler Institute of Molecular Medicine, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
Doruk ErkanBarbara Volcker Center for Women and Rheumatic Diseases, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY 10021, USA.
Andrew L GoodmanMicrobial Sciences Institute, Department of Microbial Pathogenesis, Yale School of Medicine, New Haven, CT 06536, USA.
Martin A KriegelDepartment of Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA; Department of Medicine, Section of Rheumatology, Yale School of Medicine, New Haven, CT 06510, USA. Electronic address: martin.kriegel@yale.edu.
Yale University · USBenaroya Research InstituteCornell University · USHospital for Special Surgery · USTel Aviv University · IL
Funding
Renal Physiology and Phenotyping CoreP30DK079310 · NIDDK · YALE UNIVERSITY · PI SOMLO, STEFAN · 2008 to 2022
$16.8MINTERDISCIPLINARY IMMUNOLOGY TRAINING PROGRAMT32AI007019 · NIAID · YALE UNIVERSITY · PI Carrie L. Lucas, David G. Schatz · 1985 to 2026
$14.4MProtein Structure, Stability, and Amyloid FormationZIABC010440 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI NUSSINOV, RUTH · 2009 to 2025
$11.8MBiomolecular Recognition and Binding MechanismsZIABC010441 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI NUSSINOV, RUTH · 2009 to 2025
$9.4MTRAINING PROGRAM IN INVESTIGATIVE GASTROENTEROLOGYT32DK007017 · NIDDK · YALE UNIVERSITY · PI Fred Sanford Gorelick, Liza Konnikova · 1986 to 2026
$7.1MYale Rheumatic Diseases Research Core CenterP30AR053495 · NIAMS · YALE UNIVERSITY · PI CRAFT, JOSEPH EDGAR · 2007 to 2017
$7.0MHuman Gut Commensal Cross-reactivity in Antiphospholipid SyndromeR01AI118855 · NIAID · YALE UNIVERSITY · PI KRIEGEL, MARTIN A., MEFFRE, ERIC · 2015 to 2019
$2.1MRole of Gender-associated Microbiota in Organ-specific AutoimmunityK08AI095318 · NIAID · YALE UNIVERSITY · PI KRIEGEL, MARTIN A. · 2011 to 2015
$682kCCR NIH HHS HHSN261200800001CIntramural NIH HHS ZIA BC010441NCI NIH HHS HHSN261200800001ENIAID NIH HHS K08 AI095318NIAID NIH HHS R01 AI118855NIAID NIH HHS T32 AI007019NIAMS NIH HHS P30 AR053495NIDDK NIH HHS P30 DK079310NIDDK NIH HHS T32 DK007017
Abstract
Given the immense antigenic load present in the microbiome, we hypothesized that microbiota mimotopes can be a persistent trigger in human autoimmunity via cross-reactivity. Using antiphospholipid syndrome (APS) as a model, we demonstrate cross-reactivity between non-orthologous mimotopes expressed by a common human gut commensal, Roseburia intestinalis (R. int), and T and B cell autoepitopes in the APS autoantigen β
Indexed as
AutoimmunityCross ReactionsAdultAgedAnimalsAntibodies, BacterialAntigens, BacterialAntiphospholipid SyndromeAutoantibodiesbeta 2-Glycoprotein IB-LymphocytesEubacterialesFemaleGastrointestinal TractHumansImmunoglobulin GAntibodies, BacterialAntigens, BacterialAutoantibodiesbeta 2-Glycoprotein IImmunoglobulin Gapolipoprotein HBacteroides thetaiotaomicroncalprotectinDNA methyltransferaseIgA-coated bacteriamicrobiotmemolecular mimicrysystemic autoimmunityTh1 cell clonesthrombosis
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Registered trials
NCT01787305ClinicalTrials.gov
NCT02394964ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.