ArticleJournal of the American Academy of Dermatology2019
Reflectance confocal microscopy confirms residual basal cell carcinoma on clinically negative biopsy sites before Mohs micrographic surgery: A prospective study.
Article in Journal of the American Academy of Dermatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Reflectance confocal microscopy terminology glossary for melanocytic skin lesions: A systematic review.Journal of the American Academy of Dermatology · 2021Pooled it
- In vivo imaging characterization of basal cell carcinoma and cutaneous response to high-dose ionizing radiation therapy: A prospective study of reflectance confocal microscopy, dermoscopy, and ultrasonography.Journal of the American Academy of Dermatology · 2021Trial
- Article
- A Prospective, Observational Study Evaluating the Diagnostic Performance of a Newly FDA-Approved Line-Field Optical Coherence Tomography (LC-OCT) in the Detection of Basal Cell Carcinoma.Lasers in surgery and medicine · 2026Observational
- Surgical Outcomes of Nonmelanoma Skin Cancer Managed with Systematic Preoperative Reflectance Confocal Microscopy-Guided Margin Assessment: A Retrospective Cohort Study Comparing Wide Local Excision and Mohs Micrographic Surgery.Diagnostics (Basel, Switzerland) · 2026Article
- [Use of modern imaging in dermatosurgery].Dermatologie (Heidelberg, Germany) · 2025Review
- [In vivo reflectance confocal microscopy and keratinocyte skin cancer : Reflectance confocal microscopy and artificial intelligence].Dermatologie (Heidelberg, Germany) · 2025Review
- Regression Rate of Basal Cell Carcinoma in a Veteran Population: A Study of 317 Cases at the Kansas City Veterans Affairs Medical Center.The Journal of clinical and aesthetic dermatology · 2025Article
- Combination of Fractional CODermatology practical & conceptual · 2025Article
- In Vivo Confocal Microscopy in the Surgical Treatment of Keratinocyte Carcinomas: A Systematic Review.Journal of clinical medicine · 2025Review
- Cutting-Edge Technology Without Cutting: Treating Skin Cancer in This Era-A Case Series.Cancers · 2024Article
- One-Stop Shop: Diagnosis and Treatment of Basal Cell Carcinoma in One Step.Journal of clinical medicine · 2024Review
- Combining Reflectance Confocal Microscopy, Optical Coherence Tomography and Ex-Vivo Fluorescence Confocal Microscopy for Margin Assessment in Basal Cell Carcinoma Excision.Dermatology practical & conceptual · 2024Article
- Confocal Microscopy for Diagnosis and Management of Cutaneous Malignancies: Clinical Impacts and Innovation.Diagnostics (Basel, Switzerland) · 2023Review
- Lentigo maligna melanoma mapping using reflectance confocal microscopy correlates with staged excision: A prospective study.Journal of the American Academy of Dermatology · 2023Article
- Non-invasive imaging techniques in presurgical margin assessment of basal cell carcinoma: Current evidence.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2023Article
- Review
- Emerging Minimally Invasive Technologies for the Detection of Skin Cancer.Journal of personalized medicine · 2021Review
- Optical imaging guided- 'precision' biopsy of skin tumors: a novel approach for targeted sampling and histopathologic correlation.Archives of dermatological research · 2021Observational
- Known and new facts on basal cell carcinoma.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundBiopsy specimens from patients with basal cell carcinoma (BCC) can present to surgery with no clinically residual tumor, complicating treatment decisions.
objectiveTo evaluate reflectance confocal microscopy (RCM) for the assessment of residual BCC following biopsy.
methodsConsecutive patients with biopsy-proven BCC and no clinical evidence of residual tumor who had been referred for Mohs micrographic surgery were included. Biopsy sites were imaged with a handheld RCM device. On the basis of RCM evaluation, cases were labeled RCM positive or RCM negative. Mohs micrographic surgery was performed in all cases; margins and 15-μm serial vertical sectioning were evaluated.
resultsA total of 61 patients were included (mean age, 61.7 years [standard deviation, 12.2 years]; range, 37-87 years); 60.7% were women. The mean lesion size was 5.1 mm (range, 3-12 mm); 73.8% of patients were positive on RCM, and 68.9% had residual BCC on histopathologic examination. The rates of RCM sensitivity, specificity, positive predictive value, and negative predictive value were 92.8%, 68.4%, 86.6%, and 81.2%, respectively. Three cases of BCC (high-risk, infiltrative, and basosquamous) were missed with use of RCM. When high-risk subtypes were excluded (n = 5), sensitivity and negative predictive value were both 100%. LIMITATIONS: RCM can miss deep-seated residual tumor.
conclusionRCM is a valuable tool for the evaluation of residual BCC following biopsy, with the potential to reduce unnecessary surgical procedures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.