ReviewInternational journal of oral and maxillofacial surgery2019
Clear cell odontogenic carcinoma: a rare jaw tumor. A summary of 107 reported cases.
Review in International journal of oral and maxillofacial surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Odontogenic and Maxillofacial Bone Tumours.Head and neck pathology · 2022Pooled it
- Malignant Odontogenic Tumours: A Systematic Review of Cases Reported in Literature.Frontiers in oral health · 2021Pooled it
- Malignant Odontogenic Tumors: A Clinicopathological Study of 53 Cases in Brazil.Head and neck pathology · 2026Article
- Salivary Hyalinizing Clear Cell Carcinoma and Odontogenic Clear Cell Carcinoma: A Case Series and a Scoping Review Comparing Clinicopathological Presentations.Diagnostics (Basel, Switzerland) · 2026Review
- Diagnostic Dilemma of Clear Cell Odontogenic Carcinoma Mimicking Various Pathological Entities: A Case Report and Literature Review.Clinical case reports · 2025Article
- Malignant Recurrence of Benign Odontogenic Tumors (A Single Center Cross-Sectional Study).Head and neck pathology · 2024Article
- Diagnostic Utility of EWSR1 in Clear Cell Odontogenic Carcinoma: A Systematic Review.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- Case of metastatic clear cell odontogenic carcinoma with response to chemoimmunotherapy.BMJ case reports · 2024Article
- A Comparison of Clear Cell Sarcoma to Jaw and Salivary Tumors Bearing EWS Fusions.Head and neck pathology · 2024Review
- Clear Cell Odontogenic Carcinoma: A Rare JAW Tumor-A Case Report and Literature Review.Journal of maxillofacial and oral surgery · 2024Article
- Article
- Clear cell Odontogenic Carcinoma Mandible Mimicking oral Cavity Squamous cell Carcinoma: An Intriguing case with Review of Literature.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- A Current Review of Machine Learning and Deep Learning Models in Oral Cancer Diagnosis: Recent Technologies, Open Challenges, and Future Research Directions.Diagnostics (Basel, Switzerland) · 2023Review
- Top 10 Clear Cell Head and Neck Lesions to Contemplate.Head and neck pathology · 2023Review
- Homeobox Genes in Odontogenic Lesions: A Scoping Review.Head and neck pathology · 2023Article
- Rare clear cell odontogenic carcinoma associated with impacted tooth in a young patient: case report and literature review.Oral and maxillofacial surgery · 2022Review
- Unusual Presentation of Clear Cell Odontogenic Carcinoma: Case Report and Literature Review.Diagnostics (Basel, Switzerland) · 2022Article
- Clear Cell Odontogenic Carcinoma: A Series of Three Cases.Dentistry journal · 2022Article
- Clear Cell Odontogenic Carcinoma: First Report of Novel EWSR1-CREM Fusion Gene in Case of Long-Term Misdiagnosis.Head and neck pathology · 2021Article
- Extraosseous odontogenic fibroma with a clear cells component: a 5-year follow-up.BMJ case reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
The purpose of this study was to summarize the currently published cases of clear cell odontogenic carcinoma (CCOC). The PubMed and Springer databases were used to collect available reports, searching for 'clear cell odontogenic carcinoma', 'CCOC', or 'clear cell ameloblastoma'. The search resulted in 75 reports detailing 107 cases between 1985 and 2018. Clinically the tumor manifests as a swelling in the posterior mandible (n=46), anterior mandible (n=33), and maxilla (n=28). Radiological analysis of 85 cases typically showed a poorly defined expansive radiolucency (n=83). Of the 70 patients with symptoms reported, 44 specified a swelling, 11 tooth mobility, seven gingival/periodontal issues, five numbness, and three decreased jaw opening. One patient presented with a neck mass. The duration of symptoms prior to seeking care was specified for 52 patients: 2 months to 1 year for 34 patients, 1-2 years for seven, 2-4 years for two, 4-7 years for six, and 7-12 years for three. The incidence of recurrence appeared to be 38 of the 88 cases where recurrence was reported. CCOC can be distinguished from other oral cancers by its distinctive histology and immunohistochemical characteristics and less aggressive behavior. Currently, treatment should be early and aggressive resection with clear surgical margins and long-term follow-up. The overall goal is to collect a cohort of patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.