Evidence map›Paper›PMID 31227171›Full record

ReviewCarbohydrate polymers2019

Review of polysaccharide particle-based functional drug delivery.

Thomas G Barclay, Candace Minhthu Day, Nikolai Petrovsky, Sanjay Garg

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Carbohydrate polymers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed.

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39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Thomas G BarclaySchool of Pharmacy and Medical Science, University of South Australia, Adelaide, SA 5000, Australia. Electronic address: tom.barclay@unisa.edu.au.
Candace Minhthu DaySchool of Pharmacy and Medical Science, University of South Australia, Adelaide, SA 5000, Australia. Electronic address: candace.day@mymail.unisa.edu.au.
Nikolai PetrovskyVaxine Pty Ltd, 1 Flinders Drive, Bedford Park, SA 5042, Australia; Department of Endocrinology, Flinders Medical Centre/Flinders University, Bedford Park, SA 5042, Australia. Electronic address: nikolai.petrovsky@flinders.edu.au.
Sanjay GargSchool of Pharmacy and Medical Science, University of South Australia, Adelaide, SA 5000, Australia. Electronic address: sanjay.garg@unisa.edu.au.

Funding

Novel vaccine adjuvants to counter bioterrorist threatsU01AI061142 · NIAID · FLINDERS UNIVERSITY OF SOUTH AUSTRALIA · PI PETROVSKY, NIKOLAI · 2005 to 2009
$3.5M
NIAID NIH HHS HHSN272200800039CNIAID NIH HHS HHSN272201400053CNIAID NIH HHS U01 AI061142
6 · The paper itself

Abstract

This review investigates the significant role polysaccharide particles play in functional drug delivery. The importance of these systems is due to the wide variety of polysaccharides and their natural source meaning that they can provide biocompatible and biodegradable systems with a range of both biological and chemical functionality valuable for drug delivery. This functionality includes protection and presentation of working therapeutics through avoidance of the reticuloendothelial system, stabilization of biomacromolecules and increasing the bioavailability of incorporated small molecule drugs. Transport of the therapeutic is also key to the utility of polysaccharide particles, moving drugs from the site of administration through mucosal binding and transport and using chemistry, size and receptor mediated drug targeting to specific tissues. This review also scrutinizes the methods of synthesizing and constructing functional polysaccharide particle drug delivery systems that maintain and extend the functionality of the natural polysaccharides.

Indexed as

AnimalsDrug CarriersDrug LiberationHumansPolysaccharidesDrug CarriersPolysaccharidesCarbohydrateFunctional drug-deliveryHydrogelPolysaccharide

Identifiers

PMID31227171
PMCPMC6626612

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.