Evidence map›Paper›PMID 31227029›Full record

ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2019

Pharmacokinetics of a Long-lasting, Highly Concentrated Buprenorphine Solution after Subcutaneous Administration in Rhesus Macaques (

Alexis L Mackiewicz, Gregory W Salyards, Heather K Knych, Ashley E Hill, Kari L Christe

Open access · greenAbstract readRandomized Controlled Trial, Veterinary
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Pharmacokinetics of a Transdermal Buprenorphine Topical Solution in the Cynomolgus Macaque (Macaca fascicularis).Journal of the American Association for Laboratory Animal Science : JAALAS · 2025
    Article
  3. Article
  4. Article
  5. A Review of Long-acting Parenteral Analgesics for Mice and Rats.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022
    Review
  6. Review
  7. Association of Primate Veterinarians Guidelines for Wound Management of Nonhuman Primates.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022
    Article
  8. Article
  9. Pharmacokinetics and Efficacy of a Long-lasting, Highly Concentrated Buprenorphine Solution in Rats.Journal of the American Association for Laboratory Animal Science : JAALAS · 2021
    Article
  10. Pharmacokinetics of Single-Dose Intramuscular and Subcutaneous Injections of Buprenorphine in Common Marmosets (Journal of the American Association for Laboratory Animal Science : JAALAS · 2021
    Article
  11. Predictors of Subcutaneous Injection Site Reactions to Sustained-Release Buprenorphine in Rhesus Macaques (Journal of the American Association for Laboratory Animal Science : JAALAS · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Alexis L MackiewiczDepartment of Primate Medicine, California National Primate Research Center, University of California, Davis, Davis, California;, Email: amackiewicz@ucdavis.edu.
Gregory W SalyardsDepartment of Primate Medicine, California National Primate Research Center, University of California, Davis, Davis, California.
Heather K KnychKL Maddy Equine Analytical Chemistry Laboratory, University of California, Davis, Davis, California.
Ashley E HillCalifornia Animal Health and Food Safety Laboratory, University of California, Davis, Davis, California; Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, Davis, California.
Kari L ChristeDepartment of Primate Medicine, California National Primate Research Center, University of California, Davis, Davis, California; Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, Davis, California.
University of California, Davis · USCalifornia Animal Hospital · US

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
NIH HHS P51 OD011107
6 · The paper itself

Abstract

Opioids are essential for use in rhesus macaques (

Indexed as

Analgesics, OpioidAnimalsArea Under CurveBuprenorphineCross-Over StudiesFemaleHalf-LifeInjections, SubcutaneousMacaca mulattaMalePainAnalgesics, OpioidBuprenorphine

Identifiers

PMID31227029
PMCPMC6643088
OpenAlexW2952108540

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.