Evidence map›Paper›PMID 31227020›Full record

ArticleParasites & vectors2019

Insecticide resistance mechanisms with novel 'kdr' type gene mutations in the tropical bed bug Cimex hemipterus.

Ranindra Punchihewa, W A Priyanka P de Silva, Thilini C Weeraratne, S H P Parakrama Karunaratne

Open access · goldAbstract read
In one paragraph

Article in Parasites & vectors, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 43 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Taxonomy, Bio-Ecology and Insecticide Resistance of Anopheline Vectors of Malaria in Sri Lanka.International journal of environmental research and public health · 2024
    Review
  5. Article
  6. Testing the Sensitivity of the Tropical Bed BugJournal of arthropod-borne diseases · 2023
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Widespread Mutations in Voltage-Gated Sodium Channel Gene ofInternational journal of environmental research and public health · 2021
    Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ranindra PunchihewaDepartment of Zoology, Faculty of Science, University of Peradeniya, Peradeniya, 20400, Sri Lanka.
W A Priyanka P de SilvaDepartment of Zoology, Faculty of Science, University of Peradeniya, Peradeniya, 20400, Sri Lanka.
Thilini C WeeraratneDepartment of Zoology, Faculty of Science, University of Peradeniya, Peradeniya, 20400, Sri Lanka.
S H P Parakrama KarunaratneDepartment of Zoology, Faculty of Science, University of Peradeniya, Peradeniya, 20400, Sri Lanka. shppkaru@yahoo.com.
University of Peradeniya · LK

Funding

University of Peradeniya InRC/RG/13/21
6 · The paper itself

Abstract

backgroundThe tropical bed bug, Cimex hemipterus, is a serious indoor public health pest in tropical regions causing intense physical discomfort and mental distress to humans. At present, the application of insecticides is the major control strategy. The present study was designed to evaluate the development of resistance and resistance mechanisms in Cimex hemipterus from Kandy district, Sri Lanka.

methodsThe resistance status of the collected bed bugs was determined against the discriminative dosages of DDT, malathion, propoxur, deltamethrin and permethrin by conducting bioassays according to World Health Organization guidelines. Activities of insecticide metabolizing enzymes, i.e. esterases, glutathione S-transferases (GST) and monooxygenases, and the insensitivity of organophosphate/carbamate target site acetylcholinesterase (AChE), were evaluated by biochemical assays. Regions of the gene of the pyrethroid/DDT target site, the voltage-gated sodium channel regulatory protein (VGSC), were sequenced for possible kdr mutations.

resultsSurvival percentages of bed bug population were 71, 68 and 51% for DDT, malathion and propoxur respectively. KT

conclusionsThe bed bug population has developed high resistance to propoxur with increased esterase activities. KT

Indexed as

Genes, InsectInsecticidesMutationAnimalsBedbugsBiological AssayEsterasesInsecticide ResistanceMalathionPermethrinPropoxurSri LankaEsterasesInsecticidesMalathionPermethrinPropoxurCimex hemipterusInsecticide resistancekdr type mutationsResistance mechanismsTropical bed bug

Identifiers

PMID31227020
PMCPMC6588899
OpenAlexW2953090956

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.