Evidence map›Paper›PMID 31226872›Full record

ReviewInternational journal of molecular sciences2019

Mediators of Physical Activity Protection against ROS-Linked Skeletal Muscle Damage.

Sergio Di Meo, Gaetana Napolitano, Paola Venditti

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 5 pooled it
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 5 syntheses or guidelines pooled it, 136 citations in OpenAlex.

  1. Pooled it
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  3. Effect of Tai Chi on Markers of Oxidative Stress: Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021
    Pooled it
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  6. Trial
  7. Effect of C242T Polymorphism in the Gene Encoding the NAD(P)H Oxidase p22International journal of environmental research and public health · 2020
    Trial
  8. Review
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  15. Sodium butyrate promotes the function ofFrontiers in veterinary science · 2026
    Article
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13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Sergio Di MeoDipartimento di Biologia, Università di Napoli Federico II, Complesso Universitario Monte Sant'Angelo, Via Cinthia, I-80126 Napoli, Italy. serdimeo@unina.it.
Gaetana NapolitanoDipartimento di Scienze e Tecnologie, Università degli Studi di Napoli Parthenope, via Acton n. 38-I-80133 Napoli, Italy. gaetana.napolitano@uniparthenope.it.
Paola VendittiDipartimento di Biologia, Università di Napoli Federico II, Complesso Universitario Monte Sant'Angelo, Via Cinthia, I-80126 Napoli, Italy. venditti@unina.it.
Istituto Nazionale di Fisica Nucleare, Sezione di Napoli · ITParthenope University of Naples · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Unaccustomed and/or exhaustive exercise generates excessive free radicals and reactive oxygen and nitrogen species leading to muscle oxidative stress-related damage and impaired contractility. Conversely, a moderate level of free radicals induces the body's adaptive responses. Thus, a low oxidant level in resting muscle is essential for normal force production, and the production of oxidants during each session of physical training increases the body's antioxidant defenses. Mitochondria, NADPH oxidases and xanthine oxidases have been identified as sources of free radicals during muscle contraction, but the exact mechanisms underlying exercise-induced harmful or beneficial effects yet remain elusive. However, it is clear that redox signaling influences numerous transcriptional activators, which regulate the expression of genes involved in changes in muscle phenotype. The mitogen-activated protein kinase family is one of the main links between cellular oxidant levels and skeletal muscle adaptation. The family components phosphorylate and modulate the activities of hundreds of substrates, including transcription factors involved in cell response to oxidative stress elicited by exercise in skeletal muscle. To elucidate the complex role of ROS in exercise, here we reviewed the literature dealing on sources of ROS production and concerning the most important redox signaling pathways, including MAPKs that are involved in the responses to acute and chronic exercise in the muscle, particularly those involved in the induction of antioxidant enzymes.

Indexed as

ExerciseOxidative StressAnimalsHumansMAP Kinase Signaling SystemMitochondriaMuscle FatigueMuscle, SkeletalReactive Oxygen SpeciesReactive Oxygen Speciescancercardiovascular diseaseexerciseinsulin resistancemitochondrianeurodegenerative disordersNrf2oxidative stressPGC-1UCPs

Identifiers

PMID31226872
PMCPMC6627449
OpenAlexW2949550667

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.