ArticleLife (Basel, Switzerland)2019
Prebiotic Sugar Formation Under Nonaqueous Conditions and Mechanochemical Acceleration.
Article in Life (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Comprehensive Mapping of Compositional Dynamics in the Formose Reaction Network.Angewandte Chemie (International ed. in English) · 2026Article
- Molecular war and peace: the concurrent path to antibiosis and antibiotic resistance.Frontiers in microbiology · 2026Review
- Formaldehyde and its surrogates as a C1 platform for defossilised modern societies.Chemical Society reviews · 2025Review
- Environmental History is Transferred via Minerals Altering Formose Reaction Pathways.Angewandte Chemie (International ed. in English) · 2025Article
- The second wave of formose research.BBA advances · 2025Article
- Article
- Towards a prebiotic chemoton - nucleotide precursor synthesis driven by the autocatalytic formose reaction.Chemical science · 2023Article
- Preferential formation of specific hexose and heptose in the formose reaction under microwave irradiation.RSC advances · 2023Article
- A Physicochemical Consideration of Prebiotic Microenvironments for Self-Assembly and Prebiotic Chemistry.Life (Basel, Switzerland) · 2022Review
- Towards Predicting the Sequential Appearance of Zeolitic Imidazolate Frameworks Synthesized by Mechanochemistry.Molecules (Basel, Switzerland) · 2022Article
- Potassium at the Origins of Life: Did Biology Emerge from Biotite in Micaceous Clay?Life (Basel, Switzerland) · 2022Article
- Prebiotic Pathway from Ribose to RNA Formation.International journal of molecular sciences · 2021Review
- Prebiotic Reaction Networks in Water.Life (Basel, Switzerland) · 2020Review
- Mineral-mediated carbohydrate synthesis by mechanical forces in a primordial geochemical setting.Communications chemistry · 2020Article
- Proto-Urea-RNA (Wöhler RNA) Containing Unusually Stable Urea Nucleosides.Angewandte Chemie (International ed. in English) · 2019Review
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Authors and funding
4 authors.
Funding
Abstract
Monosaccharides represent one of the major building blocks of life. One of the plausible prebiotic synthesis routes is the formose network, which generates sugars from C1 and C2 carbon sources in basic aqueous solution. We report on the feasibility of the formation of monosaccharides under physical forces simulated in a ball mill starting from formaldehyde, glycolaldehyde, DL-glyceraldehyde as prebiotically available substrates using catalytically active, basic minerals. We investigated the influence of the mechanic energy input on our model system using calcium hydroxide in an oscillatory ball mill. We show that the synthesis of monosaccharides is kinetically accelerated under mechanochemical conditions. The resulting sugar mixture contains monosaccharides with straight and branched carbon chains as well as decomposition products. In comparison to the sugar formation in water, the monosaccharides formed under mechanochemical conditions are more stable and selectively synthesized. Our results imply the possibility of a prebiotic monosaccharide origin in geochemical environments scant or devoid of water promoted by mechanochemical forces such as meteorite impacts or lithospheric activity.
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