Evidence map›Paper›PMID 31226775›Full record

ArticleMetabolites2019

A Quantitative HILIC-MS/MS Assay of the Metabolic Response of Huh-7 Cells Exposed to 2,3,7,8-Tetrachlorodibenzo-

Qing Liu, Jingwei Cai, Robert G Nichols, Yuan Tian, Jintao Zhang, Philip B Smith, Yan Wang, Chao Yan, Andrew D Patterson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Qing LiuSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China. qul76@psu.edu.
Jingwei CaiCenter for Molecular Toxicology and Carcinogenesis, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA 16802, USA. vivianna620@gmail.com.
Robert G NicholsCenter for Molecular Toxicology and Carcinogenesis, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA 16802, USA. rgn5011@psu.edu.
Yuan TianCenter for Molecular Toxicology and Carcinogenesis, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA 16802, USA. yzt11@psu.edu.ORCID 0000-0001-6174-3359
Jintao ZhangCenter for Molecular Toxicology and Carcinogenesis, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA 16802, USA. jingtao.zhang@ntu.edu.sg.ORCID 0000-0002-0846-4411
Philip B SmithHuck Institute of the Life Sciences, University Park, PA 16802, USA. pbs13@psu.edu.
Yan WangSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China. wangyan11@sjtu.edu.cn.ORCID 0000-0001-9947-6751
Chao YanSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China. chaoyan@sjtu.edu.cn.
Andrew D PattersonCenter for Molecular Toxicology and Carcinogenesis, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA 16802, USA. adp117@psu.edu.ORCID 0000-0003-2073-0070
Pennsylvania State University · USShanghai Jiao Tong University · CN

Funding

Environmental Ah Receptor Ligand Impact on the Host-Microbiome Metabolic AxisR01ES028288 · NIEHS · PENNSYLVANIA STATE UNIVERSITY, THE · PI PATTERSON, ANDREW · 2017 to 2021
$1.7M
Environmental Ah Receptor Ligand Impact on the Host-Microbiome Metabolic AxisR56ES026684 · NIEHS · PENNSYLVANIA STATE UNIVERSITY, THE · PI PATTERSON, ANDREW · 2017 to 2017
$157k
NIEHS NIH HHS 028288NIEHS NIH HHS ES026684NIEHS NIH HHS R01 ES028288Pennsylvania Department of Health Tobacco CURE FundsU.S. Department of Agriculture 4607 Accession 1009993
6 · The paper itself

Abstract

A hydrophilic interaction liquid chromatography (HILIC)-ultra high-pressure liquid chromatography (UHPLC) coupled with tandem mass spectrometry (MS/MS) method was developed and applied to profile metabolite changes in human Huh-7 cells exposed to the potent aryl hydrocarbon receptor (AHR) ligand 2,3,7,8-tetrachlorodibenzo-

Indexed as

HILIC–UHPLC–MS/MSpolar metabolitestargeted metabolomicsTCDD

Identifiers

PMID31226775
PMCPMC6631636
OpenAlexW2951005558

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.