ArticleNutrients2019
Congruency of Genetic Predisposition to Lactase Persistence and Lactose Breath Test.
Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Development of a novel SNP assay to detect lactase persistence associated genetic variants.Molecular biology reports · 2021Trial
- Knowledge of lactose intolerance in Italian adults: a cross‑sectional assessment.European journal of nutrition · 2026Article
- Lactose Residual Content in PDO Cheeses: Novel Inclusions for Consumers with Lactose Intolerance.Foods (Basel, Switzerland) · 2021Article
- A Triple Threat? The Role of Diet, Nutrition, and the Microbiota in T1D Pathogenesis.Frontiers in nutrition · 2021Review
- Clinical Utility ofNutrients · 2020Observational
- Article
- Nutritional management of lactose intolerance: the importance of diet and food labelling.Journal of translational medicine · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The physiological decline of lactase production in adulthood, in some individuals, is responsible for the so-called "Lactose Intolerance." This clinical syndrome presents with gastrointestinal and non-gastrointestinal symptoms following the consumption of dairy containing food. Lactose intolerance can be evaluated by means of the Lactose Breath Test (phenotype) and/or genetic evaluation of lactase-gene polymorphism (genotype). A comparison of the two tests was carried out in a large number of symptomatic adult subjects, which are selected and not representative of the general population. Congruency was as high as 88.6%. Among lactase non-persistent (genotype C/C), 14 subjects showed a negative Lactose Breath Test (LBT), possibly due to young age. Among lactase-persistent (genotype C/T), four subjects showed a positive LBT, which helps to diagnose secondary lactose intolerance. Symptoms, both gastrointestinal and extra-gastrointestinal, were reported by 90% of patients during the breath test. Clinical use of both tests in the same patients could be taken into consideration as a sharp diagnostic tool. We suggest considering the use of the genetic test after LBT administration, when secondary hypolactasia is suspected, for completion of diagnostic procedures.
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Registered trials
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