ArticleEnvironment international2019
Temporal variability in urinary pesticide concentrations in repeated-spot and first-morning-void samples and its association with oxidative stress in healthy individuals.
Article in Environment international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Pesticides and neurodevelopment of children in low and middle-income countries: A systematic review.PloS one · 2025Pooled it
- Low-dose exposure to organophosphate pesticides and chronic kidney disease: insights from urinary dialkyl phosphate biomarkers.Clinical and experimental nephrology · 2026Article
- Associations between concurrent neonicotinoid, pyrethroid, and organophosphate insecticide metabolites and neurocognitive performance in Ecuadorian adolescents.The Science of the total environment · 2025Article
- A Novel Approach to Integrate Human Biomonitoring Data with Model Predicted Dietary Exposures: A Crop Protection Chemical Case Study Using Lambda-Cyhalothrin.Journal of agricultural and food chemistry · 2024Article
- Differential Occupational Health Risks between Methylated PAHs and PAHs: Monitoring 126 PAHs and 6 Oxidative Stress Markers in Paired Serum-Urine Samples.Environment & health (Washington, D.C.) · 2024Article
- The Role ofToxics · 2023Article
- Neurodegenerative Diseases: Implications of Environmental and Climatic Influences on Neurotransmitters and Neuronal Hormones Activities.International journal of environmental research and public health · 2022Review
- Pyrimethanil and chlorpyrifos air concentrations and pregnant women's urinary metabolites in the Infants' Environmental Health Study (ISA), Costa Rica.Environment international · 2022Article
- Prenatal Exposure to Organophosphorus Pesticides and Preschool ADHD in the Norwegian Mother, Father and Child Cohort Study.International journal of environmental research and public health · 2022Article
- Diurnal variability in urinary volatile organic compound metabolites and its association with oxidative stress biomarkers.The Science of the total environment · 2022Article
- Analysis of 19 urinary biomarkers of oxidative stress, nitrative stress, metabolic disorders, and inflammation using liquid chromatography-tandem mass spectrometry.Analytical and bioanalytical chemistry · 2022Article
- Effect of Flutriafol Exposure on Residue Characteristics in Pig Muscle and Fat Tissue.Food science of animal resources · 2022Article
- Variability in urinary biomarkers of human exposure to polycyclic aromatic hydrocarbons and its association with oxidative stress.Environment international · 2021Article
- Organophosphate pesticide exposure: Demographic and dietary predictors in an urban pregnancy cohort.Environmental pollution (Barking, Essex : 1987) · 2021Article
- Non-Occupational Exposure to Pesticides: Experimental Approaches and Analytical Techniques (from 2019).Molecules (Basel, Switzerland) · 2021Review
- Characteristics of Exposure of Reproductive-Age Farmworkers in Chiang Mai Province, Thailand, to Organophosphate and Neonicotinoid Insecticides: A Pilot Study.International journal of environmental research and public health · 2020Article
- Predictors of Urinary Pyrethroid and Organophosphate Compound Concentrations among Healthy Pregnant Women in New York.International journal of environmental research and public health · 2020Article
- Association of urinary metabolites of organophosphate and pyrethroid insecticides, and phenoxy herbicides with endometriosis.Environment international · 2020Article
- Variability in urinary neonicotinoid concentrations in single-spot and first-morning void and its association with oxidative stress markers.Environment international · 2020Article
- Prenatal exposure to organophosphate pesticides, maternal paraoxonase 1 genotype, and childhood neurodevelopment at 24 months of age in Shandong, China.Environmental science and pollution research international · 2020Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
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Abstract
Exposure of humans to pesticides is widespread. Measurement of urinary levels of pesticides and their metabolites is often used in the assessment of body burdens and exposure doses to these chemicals. An understanding of temporal variability in urinary levels of pesticides within individuals is critical for accurate exposure assessment. We examined within- and between-individual variability in concentrations of nine organophosphate and pyrethroid insecticides as well as two phenoxy herbicides in urine collected consecutively for up to 44 days from 19 individuals. Seven oxidative stress biomarkers also were measured in urine samples to elucidate their relationship with pesticide exposure. Intraclass correlation coefficients (ICCs) were calculated to assess reproducibility in urinary pesticide concentrations from repeated measures. Sensitivity and specificity analyses were performed to evaluate the suitability of spot urine to characterize average exposures. Data analysis was further limited to seven pesticides and their metabolites, which had a detection frequency of >60%. Poor reproducibility was found for the seven pesticides and their metabolites in both spot (ICCs ≤0.24) and first-morning-void (FMV) samples (ICCs <0.38) collected during the 44-day study period. Use of single-spot or FMV sample to classify high (top 33%) concentrations showed high specificities (0.73-0.85) but low sensitivities (0.45-0.70). The minimum number of samples (k) required per individual to estimate participant-specific mean value for pesticides (within 20% of the "true" values) were 28-140 and 18-119 for spot and FMV samples, respectively. Repeated longitudinal measurements of these pesticides and their metabolites in urine showed considerable within-individual variability in both spot and FMV samples. Urinary concentrations of seven pesticides and their metabolites were significantly correlated with oxidative damage to lipids, proteins, and DNA.
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