Evidence map›Paper›PMID 31226354›Full record

ReviewMetabolism: clinical and experimental2019

New developments in our understanding of vitamin metabolism, action and treatment.

Sylvia Christakos, Shanshan Li, Jessica De La Cruz, Daniel D Bikle

Open access · greenAbstract readReview
In one paragraph

Review in Metabolism: clinical and experimental, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 3 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 3 syntheses or guidelines pooled it, 96 citations in OpenAlex.

  1. Pooled it
  2. Vitamin D Deficiency in Testicular Cancer Survivors: A Systematic Review.International journal of molecular sciences · 2021
    Pooled it
  3. Efficacy of Vitamin DNutrients · 2020
    Pooled it
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  7. Review
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  11. Observational
  12. Article
  13. 1,25(OH)Clinical rheumatology · 2025
    Article
  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Sylvia ChristakosDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers, the State University of New Jersey, New Jersey Medical School, Newark, NJ, USA. Electronic address: christak@njms.rutgers.edu.
Shanshan LiDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers, the State University of New Jersey, New Jersey Medical School, Newark, NJ, USA.
Jessica De La CruzDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers, the State University of New Jersey, New Jersey Medical School, Newark, NJ, USA.
Daniel D BikleDepartments of Medicine and Dermatology, University of California and VA Medical Center, San Francisco, CA, USA.
Rutgers, The State University of New Jersey · USSan Francisco VA Medical Center · US

Funding

Nutrigenomics of Intestinal Vitamin D ActionR01DK112365 · NIDDK · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI SYLVIA S CHRISTAKOS, James C. Fleet · 2017 to 2026
$4.2M
Role of IGF-I/integrin signaling in the periosteal response to loadR01AR055924 · NIAMS · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI BIKLE, DANIEL DAVID · 2008 to 2019
$3.5M
VITAMIN D HORMONE--FUNCTION AND MECHANISM OF ACTIONR01DK038961 · NIDDK · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI CHRISTAKOS, SYLVIA S · 1987 to 2010
$3.2M
Osteoporosis and Molecular Targets of Vitamin DR21AG044552 · NIA · RBHS-NEW JERSEY MEDICAL SCHOOL · PI CHRISTAKOS, SYLVIA S · 2014 to 2015
$354k
Vitamin D and Calcium signaling in epidermal stem cell maintenance, activation, and functionI01BX003814 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI BIKLE, DANIEL DAVID · 2018 to 2021
–
BLRD VA I01 BX003814NIAMS NIH HHS R01 AR055924NIA NIH HHS R21 AG044552NIDDK NIH HHS R01 DK038961NIDDK NIH HHS R01 DK112365
6 · The paper itself

Abstract

Although vitamin D has been reported to have pleiotropic effects including effects on the immune system and on cancer progression, the principal action of vitamin D is the maintenance of calcium and phosphate homeostasis. The importance of vitamin D in this process is emphasized by the consequences of vitamin D deficiency which includes rickets in children and osteomalacia in adults. Vitamin D deficiency has also been reported to increase the risk of falls and osteoporotic fractures. Although vitamin D fortification of foods (including dairy products) has contributed to a marked decrease in rickets in the Western world, vitamin D deficiency in children and adults is still prevalent world-wide. This review summarizes new developments in our understanding of vitamin D endocrine system and addresses clinical syndromes related to abnormalities in vitamin D metabolism and action. In addition, the current understanding of the evaluation of vitamin D deficiency and sufficiency and recommendations for achieving vitamin D sufficiency are discussed.

Indexed as

AnimalsBone and BonesBone DensityHumansVitamin DVitamin D DeficiencyVitamin DBoneCalcium homeostasisFibroblast growth factor 23IntestineKidneyParathyroid hormoneRandomized controlled clinical trialsVitamin DVitamin D metabolism

Identifiers

PMID31226354
PMCPMC6814307
OpenAlexW2949740564

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.