ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019
A critical role for estrogen signaling in penis development.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- The potential mechanisms underlying phthalate-induced hypospadias: a systematic review of rodent model studies.Frontiers in endocrinology · 2024Pooled it
- Revisiting the dual role of androgens and oestrogens in mammalian sex differentiation with a focus on genitalia.Nature reviews. Urology · 2026Review
- Gonadal Function and Its Evolution in 46,XX Testicular/Ovotesticular DSD.The Journal of clinical endocrinology and metabolism · 2026Article
- Intrauterine Exposure to Endocrine-disrupting Chemicals and Risk of Hypospadias: A Pilot Study.Journal of the Endocrine Society · 2026Article
- Morphological, Histochemical and Immunohistochemical Characterisation of the Penis in Free-Ranging Giant Anteaters (Myrmecophaga tridactyla).Anatomia, histologia, embryologia · 2025Article
- Expression Dynamics and Estrogen Response of Estrogen Receptors in Duolang Sheep During Puberty.Genes · 2025Article
- Bibliometric analysis of hypospadias from 1998-2023.Frontiers in surgery · 2025Article
- Androgen receptor antagonist flutamide modulates estrogen receptor alpha expression in distinct regions of the hypospadiac rat penis.Frontiers in endocrinology · 2025Article
- Identification and analysis of epithelial-mesenchymal transition-related key long non-coding RNAs in hypospadias.IET systems biology · 2024Article
- New uses for an old technique: live imaging on the slice organ culture to study reproductive processes†.Biology of reproduction · 2024Article
- Estrogenic endocrine disruptor exposure directly impacts erectile function.Communications biology · 2024Article
- A Genetics Study in the Foreskin of Boys with Hypospadias.Molecular syndromology · 2023Article
- Simultaneous Occurrence of Hypospadias and Bilateral Cleft Lip and Jaw in a Crossbred Calf: Clinical, Computer Tomographic, and Genomic Characterization.Animals : an open access journal from MDPI · 2023Article
- Neoadjuvant Chemotherapy in Pregnant Patients with Cervical Cancer: A Monocentric Retrospective Study.Current oncology (Toronto, Ont.) · 2022Article
- One Tool for Many Jobs: Divergent and Conserved Actions of Androgen Signaling in Male Internal Reproductive Tract and External Genitalia.Frontiers in endocrinology · 2022Review
- Developmental and sexual dimorphic atlas of the prenatal mouse external genitalia at the single-cell level.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Endocrine disrupting chemicals in the pathogenesis of hypospadias; developmental and toxicological perspectives.Current research in toxicology · 2021Review
- Exogenous Oestrogen Impacts Cell Fate Decision in the Developing Gonads: A Potential Cause of Declining Human Reproductive Health.International journal of molecular sciences · 2020Review
- Estrogen suppresses SOX9 and activates markers of female development in a human testis-derived cell line.BMC molecular and cell biology · 2020Article
- Androgens and the masculinization programming window: human-rodent differences.Biochemical Society transactions · 2020Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Hypospadias, a developmental defect of the penis, is one of the most common congenital malformations in humans. Its incidence has rapidly increased over recent decades, and this has been largely attributed to our increased exposure to endocrine-disrupting chemicals. Penis development is primarily an androgen-driven process; however, estrogen and xenoestrogens are known to affect penis development in both humans and mice. Here, we investigated the role of estrogen in the developing penis. Using a novel penis culture system, we showed that exogenous estrogen directly targets the developing penis
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.