ArticleThe Journal of clinical endocrinology and metabolism2019
Atg7 Knockdown Reduces Chemerin Secretion in Murine Adipocytes.
Article in The Journal of clinical endocrinology and metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Novel perspectives on autophagy-oxidative stress-inflammation axis in the orchestration of adipogenesis.Frontiers in endocrinology · 2024Review
- Ablation of endothelialAutophagy · 2023Article
- Chemerin-9 Attenuates Experimental Abdominal Aortic Aneurysm Formation in ApoEJournal of oncology · 2021Article
- Communication Between Autophagy and Insulin Action: At the Crux of Insulin Action-Insulin Resistance?Frontiers in cell and developmental biology · 2021Review
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Authors and funding
13 authors at 4 institutions in 3 countries.
Funding
Abstract
contextIn individuals with obesity, adipocyte endocrine function is affected by altered autophagy. Genetic variants in autophagy-related gene 7 (ATG7) correlated with serum chemerin (RARRES2) concentrations.
objectivesTo investigate a functional interplay between chemerin and ATG7, how it may relate to autophagy-mediated adipocyte dysfunction in obesity, and the relevance of genetic ATG7 variants in chemerin physiology.
designAdipose ATG7 mRNA expression and adiposity measures were available in two human study cohorts. The effect of a high-calorie diet on adipose Rarres2 and Atg7 expression was investigated in mice. In 3T3-L1 adipocytes, the effect of Atg7 knockdown on chemerin expression and secretion was studied. The influence of single nucleotide polymorphisms on ATG7 transcription and chemerin physiology was investigated using a luciferase assay.
settingMouse model, clinical trials, in vitro studies.
participantsNative American (n = 83) and white (n = 100) cohorts.
main outcome measureAdipocyte chemerin expression and secretion.
resultsIn mice fed a high-calorie diet, adipose Atg7 mRNA expression did not parallel an increase in Rarres2 mRNA expression. ATG7 mRNA expression in human subcutaneous adipose tissue correlated with body mass index, fat mass (r > 0.27; P < 0.01), and adipocyte cell size (r > 0.24; P < 0.02). Atg7 knockdown in 3T3-L1 adipocytes decreased chemerin secretion by 22% (P < 0.04). Rs2606729 in ATG7 was predicted to alter ATG7 transcription and induced higher luciferase activity in vitro (P < 0.0001).
conclusionsHuman adipose ATG7 mRNA expression relates to measures of adiposity. Atg7 knockdown reduces chemerin secretion from adipocytes in vitro, supportive of a functional interplay between ATG7 and chemerin in autophagy-mediated adipocyte dysfunction.
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