Evidence map›Paper›PMID 31225797›Full record

ArticleeLife2019

Scc2 counteracts a Wapl-independent mechanism that releases cohesin from chromosomes during G1.

Madhusudhan Srinivasan, Naomi J Petela, Johanna C Scheinost, James Collier, Menelaos Voulgaris, Maurici B Roig, Frederic Beckouët, Bin Hu, Kim A Nasmyth

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Madhusudhan SrinivasanDepartment of Biochemistry, University of Oxford, Oxford, United Kingdom.ORCID 0000-0001-5676-4219
Naomi J PetelaDepartment of Biochemistry, University of Oxford, Oxford, United Kingdom.
Johanna C ScheinostDepartment of Biochemistry, University of Oxford, Oxford, United Kingdom.
James CollierDepartment of Biochemistry, University of Oxford, Oxford, United Kingdom.
Menelaos VoulgarisDepartment of Biochemistry, University of Oxford, Oxford, United Kingdom.
Maurici B RoigDepartment of Biochemistry, University of Oxford, Oxford, United Kingdom.
Frederic BeckouëtLaboratoire de Biologie Moléculaire Eucaryote, Centre de Biologie Intégrative (CBI), Université de Toulouse, Toulouse, France.
Bin HuDepartment of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, United Kingdom.
Kim A NasmythDepartment of Biochemistry, University of Oxford, Oxford, United Kingdom.ORCID 0000-0001-7030-4403
University of Oxford · GBUniversité Fédérale de Toulouse Midi-Pyrénées · FRUniversity of Sheffield · GB

Funding

Cancer Research UK 26747
6 · The paper itself

Abstract

Cohesin's association with chromosomes is determined by loading dependent on the Scc2/4 complex and release due to Wapl. We show here that Scc2 also actively maintains cohesin on chromosomes during G1 in

Indexed as

Calcium-Transporting ATPasesCell Cycle ProteinsChromosomal Proteins, Non-HistoneChromosomes, FungalCohesinsMolecular ChaperonesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsCalcium-Transporting ATPasesCell Cycle ProteinsChromosomal Proteins, Non-HistoneCohesinsMolecular ChaperonesRAD61 protein, S cerevisiaeSaccharomyces cerevisiae ProteinsSCC2 protein, S cerevisiaeSMC3 protein, S cerevisiaeSSC1 protein, S cerevisiaeCDK1chromosomesCohesingene expressionloop extrusionS. cerevisiaesister chromatid cohesionSMCWapl

Identifiers

PMID31225797
PMCPMC6588348
OpenAlexW2949536628

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.