Evidence map›Paper›PMID 31225515›Full record

ArticleFASEB bioAdvances2019

Structural determinants and genetic modifications enhance BMP2 stability and extracellular secretion.

Vinayak Khattar, Joo Hyoung Lee, Hong Wang, Soniya Bastola, Selvarangan Ponnazhagan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB bioAdvances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Vinayak KhattarDepartment of Pathology, The University of Alabama at Birmingham, Birmingham, AL 35294.
Joo Hyoung LeeDepartment of Pathology, The University of Alabama at Birmingham, Birmingham, AL 35294.
Hong WangDepartment of Pathology, The University of Alabama at Birmingham, Birmingham, AL 35294.
Soniya BastolaDepartment of Neurosurgery, The University of Alabama at Birmingham, Birmingham, AL 35294.
Selvarangan PonnazhaganDepartment of Pathology, The University of Alabama at Birmingham, Birmingham, AL 35294.
University of Alabama at Birmingham · US

Funding

Targeted therapy for breast cancer with osteolytic bone damageR01CA184770 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI PONNAZHAGAN, SELVARANGAN · 2015 to 2019
$1.7M
Targeted Stem Cell Therapy Coupling Angiogenesis and Osteogenesis for Bone DefectR01AR060948 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI PONNAZHAGAN, SELVARANGAN · 2011 to 2016
$1.6M
NCI NIH HHS R01 CA184770NIAMS NIH HHS R01 AR060948
6 · The paper itself

Abstract

The short half-life and use of recombinant bone morphogenetic protein (BMP)-2 in large doses poses major limitations in the clinic. Events regulating post-translational processing and degradation of BMP2

Indexed as

BMP2proteasomal degradationprotein turnoverubiquitination

Identifiers

PMID31225515
PMCPMC6586023
OpenAlexW2950344956

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.