Evidence map›Paper›PMID 31225501›Full record

ArticleCell stress2019

Development of novel methods that monitor necroptosis and the release of DAMPs at the single cell resolution.

Hiroyasu Nakano, Shin Murai, Yoshifumi Yamaguchi, Yoshitaka Shirasaki, Osamu Nakabayashi, Soh Yamazaki

Open access · goldAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell stress, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

  1. Anti-DAMP therapies for acute inflammation.Frontiers in immunology · 2025
    Review
  2. Article
  3. Article
  4. Review
  5. Release mechanisms of major DAMPs.Apoptosis : an international journal on programmed cell death · 2021
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Hiroyasu NakanoDepartment of Biochemistry, Toho University School of Medicine, 5-21-16 Omori-Nishi, Ota-ku, Tokyo 143-8540, Japan.
Shin MuraiDepartment of Biochemistry, Toho University School of Medicine, 5-21-16 Omori-Nishi, Ota-ku, Tokyo 143-8540, Japan.
Yoshifumi YamaguchiHibernation metabolism, physiology, and development Group, Environmental Biology Division, Institute of Low Temperature Science, Hokkaido University, Kita 19, Nishi 8, Kita-ku, Sapporo, Hokkaido 060-0819, Japan.
Yoshitaka ShirasakiPrecursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Chiyoda-ku, Tokyo 102-0075, Japan.
Osamu NakabayashiDepartment of Biochemistry, Toho University School of Medicine, 5-21-16 Omori-Nishi, Ota-ku, Tokyo 143-8540, Japan.
Soh YamazakiDepartment of Biochemistry, Toho University School of Medicine, 5-21-16 Omori-Nishi, Ota-ku, Tokyo 143-8540, Japan.
Toho University · JPHokkaido University · JPJapan Science and Technology Agency · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Necroptosis is a regulated form of necrosis that depends on receptor-interacting protein kinase (RIPK)3 and mixed lineage kinase domain-like protein (MLKL). While danger-associated molecular pattern (DAMP)s are released from dead cells and involved in various pathological conditions, the mechanisms underlying regulation of the release of DAMPs are not fully understood. Apoptosis and pyroptosis can be detected by several types of sensors such as Forster resonance energy transfer (FRET) biosensors, termed SCAT1 (a sensor for caspase 1 activation based on FRET) and SCAT3, respectively. These sensors have provided better understanding of pyroptosis and apoptosis

Indexed as

danger-associated molecular pattern (DAMP)sForster resonance energy transfer (FRET)high mobility group (HMGB)1mixed lineage kinase domain-like protein (MLKL)necroptosisreceptor-interacting kinase (RIPK)3the endosomal sorting complex required for transport (ESCRT) complextotal internal reflection fluorescent microscope (TIRF-M)

Identifiers

PMID31225501
PMCPMC6551708
OpenAlexW2913040393

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.