Evidence map›Paper›PMID 31225443›Full record

ArticleCell stress2017

New insight into the role of autophagy in tumorigenesis.

Yongjun Tian, Linya Wang, Jing-Hsiung James Ou

Open access · goldAbstract readComment
In one paragraph

Article in Cell stress, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 78% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yongjun TianDepartment of Hematology, Quest Diagnostics Inc, West Hills, Los Angeles, California, USA.
Linya WangDepartment of Molecular Microbiology and Immunology, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
Jing-Hsiung James OuDepartment of Molecular Microbiology and Immunology, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
University of Southern California · US

Funding

Hepatitis C virus and autophagic responseR01DK094652 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI OU, J.-H. JAMES · 2011 to 2020
$3.2M
HBV replication and carcinogenesisR01CA177337 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI OU, J.-H. JAMES · 2013 to 2015
$583k
NCI NIH HHS R01 CA177337NIDDK NIH HHS R01 DK094652
6 · The paper itself

Abstract

Autophagy plays an important role in maintaining cellular homeostasis. Its dysfunction can cause many diseases, including neurodegenerative diseases, metabolic diseases and cancer. The role of autophagy in carcinogenesis is complex, as it was shown to have pro-tumorigenic functions in some reports, but anti-tumorigenic functions in others. By using mice with hepatocyte-specific knockout of

Indexed as

autophagyhepatic cancer stem cellshepatocarcinogenesismitophagyp53PINK1

Identifiers

PMID31225443
PMCPMC6551633
OpenAlexW2773510683

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.