Evidence map›Paper›PMID 31223628›Full record

ArticleOrthopaedic journal of sports medicine2019

One-Step Autologous Minced Cartilage Procedure for the Treatment of Knee Joint Chondral and Osteochondral Lesions: A Series of 27 Patients With 2-Year Follow-up.

Felix Kurt Massen, Cyril Raphael Inauen, Laurent Pascale Harder, Armin Runer, Stefan Preiss, Gian Max Salzmann

2 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Orthopaedic journal of sports medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04785092 nacompletednot on this mapstarted 2021, after this paper: background citation

All Autologous Cartilage Regeneration in the Treatment of the Knee Cartilage Defects: Pilot Study

TypeinterventionalSponsorIstituto Ortopedico RizzoliRan2021 to 2025Enrolled20ConditionsCartilage Damage, Cartilage DiseaseArmsAll Autologous Cartilage Regeneration
NCT07641868 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Management of Focal Cartilage Lesions of the Knee: The Benefits of an Autograft Procedure

TypeinterventionalSponsorLouis Pasteur Santé LorraineRan2026 to 2030Enrolled80ConditionsFocal Cartilage Lesions of the KneeArmsManagement of focal cartilage lesions of the knee: micro-fracture, Minced Cartilage Implantation (MCI)
3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 114 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Felix Kurt MassenLower Extremity Orthopaedics, Musculoskeletal Centre, Schulthess Clinic, Zurich, Switzerland.    F.K.M. and C.R.I. contributed equally to this work.
Cyril Raphael InauenLower Extremity Orthopaedics, Musculoskeletal Centre, Schulthess Clinic, Zurich, Switzerland.    F.K.M. and C.R.I. contributed equally to this work.
Laurent Pascale HarderLower Extremity Orthopaedics, Musculoskeletal Centre, Schulthess Clinic, Zurich, Switzerland.    F.K.M. and C.R.I. contributed equally to this work.
Armin RunerLower Extremity Orthopaedics, Musculoskeletal Centre, Schulthess Clinic, Zurich, Switzerland.    F.K.M. and C.R.I. contributed equally to this work.
Stefan PreissLower Extremity Orthopaedics, Musculoskeletal Centre, Schulthess Clinic, Zurich, Switzerland.    F.K.M. and C.R.I. contributed equally to this work.
Gian Max SalzmannLower Extremity Orthopaedics, Musculoskeletal Centre, Schulthess Clinic, Zurich, Switzerland.    F.K.M. and C.R.I. contributed equally to this work.
Schulthess-Klinik · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChondral and osteochondral lesions are being detected with increasing frequency. For large-diameter lesions, cell-based treatment modalities are speculated to result in the best possible outcome. PURPOSE: To prospectively evaluate the 2-year clinical and radiological results after the treatment of chondral and osteochondral knee joint lesions by a single-step autologous minced cartilage procedure. STUDY

designCase series; Level of evidence, 4.

methodsFrom February 2015 to June 2016, a total of 27 consecutive patients suffering from chondral or osteochondral lesions of the knee joint were treated using a single-step autologous minced cartilage procedure. All patients underwent preoperative and postoperative magnetic resonance imaging for the collection of AMADEUS (Area Measurement and Depth and Underlying Structures) and MOCART (magnetic resonance observation of cartilage repair tissue) scores. Clinical analysis was conducted by a numeric analog scale (NAS) for pain and knee function before the intervention and at 12 and 24 months postoperatively.

resultsA total of 12 female and 15 male patients (mean age, 28.7 years) were evaluated for a mean of 28.2 ± 3.8 months. The mean cartilage defect size encountered intraoperatively was 3.1 ± 1.6 cm

conclusionOverall, the findings of this study demonstrated that patients undergoing a single-step autologous minced cartilage procedure had a satisfactory outcome at 2-year follow-up. As a result, the single-step autologous minced cartilage procedure does represent a possible alternative to standard autologous chondrocyte implantation. Longer follow-up and larger cohorts are required to define the benefits of this procedure.

Indexed as

articular cartilagearticular cartilage resurfacingcartilage lesionchondral lesionkneeminced cartilage

Identifiers

PMID31223628
PMCPMC6566484
OpenAlexW2950380599

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.