Evidence map›Paper›PMID 31223619›Full record

ArticleBioMed research international2019

mTORC2 Regulates Lipogenic Gene Expression through PPAR

Zhixin Guo, Keyu Zhao, Xue Feng, Dandan Yan, Ruiyuan Yao, Yuhao Chen, Lili Bao, Zhigang Wang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Circadian GeneBiology · 2021
    Article
  6. Review
  7. IntracellularFrontiers in veterinary science · 2021
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Zhixin GuoState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010021, China.ORCID 0000-0003-4548-1736
Keyu ZhaoState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010021, China.ORCID 0000-0003-4263-1663
Xue FengState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010021, China.ORCID 0000-0002-1028-7426
Dandan YanState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010021, China.ORCID 0000-0003-0284-2458
Ruiyuan YaoState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010021, China.ORCID 0000-0002-5422-2843
Yuhao ChenState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010021, China.
Lili BaoState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010021, China.ORCID 0000-0003-4498-5932
Zhigang WangState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010021, China.ORCID 0000-0002-6818-2205
Inner Mongolia University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mechanistic target of rapamycin complex 2 (mTORC2) primarily functions as an effector of insulin/PI3K signaling to regulate cell proliferation and is associated with cell metabolism. However, the function of mTORC2 in lipid metabolism is not well understood. In the present study, mTORC2 was inactivated by the ATP-competitive mTOR inhibitor AZD8055 or shRNA targeting

Indexed as

Acetyl-CoA CarboxylaseAnimalsCattleCell ProliferationDiacylglycerol O-AcyltransferaseEpithelial CellsFatty Acid Synthase, Type IFemaleGene Expression Regulation, EnzymologicLipogenesisMammary Glands, AnimalMechanistic Target of Rapamycin Complex 2MorpholinesPhosphatidate PhosphatasePPAR gammaRapamycin-Insensitive Companion of mTOR Protein(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanolAcetyl-CoA CarboxylaseDiacylglycerol O-AcyltransferaseFatty Acid Synthase, Type IMechanistic Target of Rapamycin Complex 2MorpholinesPhosphatidate PhosphatasePPAR gammaRapamycin-Insensitive Companion of mTOR Protein

Identifiers

PMID31223619
PMCPMC6541957
OpenAlexW2945482821

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.