ArticleCurrent dermatology reports2018
Healing Chronic Wounds: Current Challenges and Potential Solutions.
Article in Current dermatology reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The role of cluster of differentiation 163-positive macrophages in wound healing: a preliminary study and a systematic review.Archives of dermatological research · 2023Pooled it
- Is Shock Wave Application Effective on Various Chronic Wounds in the Geriatric Population? Preliminary Clinical Study.Clinical interventions in aging · 2024Trial
- DianDao San Promotes CSU Wound Healing by Inhibiting TNF/NF-κB Pathway.Applied biochemistry and biotechnology · 2026Article
- Review
- Cell-based cytokine patch for localized immunomodulation and accelerated healing in rodent and porcine wounds.Nature biomedical engineering · 2026Article
- Rethinking Chronic Wound Treatment: Unlocking the Potential of Combination Products for an Unmet Multifactorial Need: A Review Study.Health science reports · 2026Article
- A novel chitosan-collagen bilayer scaffold prevents contraction and accelerates cutaneous repair in a rat splint-skin model.Frontiers in bioengineering and biotechnology · 2026Article
- Liposome-based drug delivery systems for skin wound healing: a promising drug delivery strategy.Frontiers in bioengineering and biotechnology · 2026Review
- Chronic Wound Healing: Breakthrough Strategies Based on Inorganic Polyphosphate.Progress in molecular and subcellular biology · 2026Review
- Single-cell reanalysis identifies macrophage-associated transcriptional and intercellular communication features in diabetic foot ulcers.Frontiers in cellular and infection microbiology · 2026Article
- Scaffolds with spatiotemporally controlled growth factor delivery and cyclodextrin-enabled antagonism of growth factor receptor sequestration promote cutaneous wound healing.NPJ Regenerative medicine · 2025Article
- Programmed wound healing in aged skin may be enhanced by mesenchymal cell loaded gene-activated scaffolds.APL bioengineering · 2025Article
- Observational
- Self-Healing Hydrogel Dressing with Solubilized Flavonoids for Whole Layer Regeneration of Diabetic Wound.Advanced healthcare materials · 2025Article
- Advancements in Wound Dressing Materials: Highlighting Recent Progress in Hydrogels, Foams, and Antimicrobial Dressings.Gels (Basel, Switzerland) · 2025Review
- Exosomes: the future of acellular nanotherapeutics in regenerative vascularization.Frontiers in bioengineering and biotechnology · 2025Review
- Carbon nanotubes for wound healing: material design, mechanistic insights.Frontiers in bioengineering and biotechnology · 2025Review
- Deficient functional wound closure as measured by elevated trans-epidermal water loss predicts chronic wound recurrence: An exploratory observational study.Scientific reports · 2024Observational
- In situ light-activated materials for skin wound healing and repair: A narrative review.Bioengineering & translational medicine · 2024Review
- NeutralizingACS omega · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
purpose of reviewThe purpose of this review is to raise awareness, examine the challenges faced by wound care researchers and explore opportunities for potential improvements. RECENT
findingsChronic wounds are associated with significant morbidity and mortality, and they represent a major medical and financial burden. Despite this, no new therapy has received FDA efficacy approval for the treatment of chronic wounds since 1997. Previous preclinical studies using animal models did not translate to human wounds due to inherent limitations of experimental models, variability in assessment methods and overall experimental design. Clinical trials continued to be challenged by the balance of the inclusion and exclusion criteria, the high cost and time expenditure of the trials, and the constraint of a single FDA-acceptable outcome of complete wound closure. SUMMARY: Wound research faces multiple challenges in both pre-clinical and clinical research that slowed progress and development of efficacious therapies. Solutions to such challenges will provide new opportunities for improved study design in the future.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.