Evidence map›Paper›PMID 31223483›Full record

ArticleMultiple sclerosis journal - experimental, translational and clinical

No differential gene expression for CD4

Ina S Brorson, Anna Eriksson, Ingvild S Leikfoss, Elisabeth G Celius, Pål Berg-Hansen, Lisa F Barcellos, Tone Berge, Hanne F Harbo, Steffan D Bos

Open access · goldAbstract read
In one paragraph

Article in Multiple sclerosis journal - experimental, translational and clinical. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. An autoimmune transcriptional circuit drives FOXP3Science translational medicine · 2024
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. RNA Sequencing of CD4Journal of molecular neuroscience : MN · 2021
    Article
  7. CSF-resident CD4Brain communications · 2021
    Article
  8. CD8Multiple sclerosis journal - experimental, translational and clinical
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ina S BrorsonInstitute of Clinical Medicine, University of Oslo, Norway.
Anna ErikssonInstitute of Clinical Medicine, University of Oslo, Norway.
Ingvild S LeikfossInstitute of Clinical Medicine, University of Oslo, Norway.
Elisabeth G CeliusInstitute of Clinical Medicine, University of Oslo, Norway.
Pål Berg-HansenInstitute of Clinical Medicine, University of Oslo, Norway.
Lisa F BarcellosComputational Biology Graduate Group, University of California, USA.
Tone BergeDepartment of Neurology, Oslo University Hospital, Norway.
Hanne F HarboInstitute of Clinical Medicine, University of Oslo, Norway.
Steffan D BosInstitute of Clinical Medicine, University of Oslo, Norway.ORCID https://orcid.org/0000-0002-2975-7520
Oslo University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMultiple sclerosis-associated genetic variants indicate that the adaptive immune system plays an important role in the risk of developing multiple sclerosis. It is currently not well understood how these multiple sclerosis-associated genetic variants contribute to multiple sclerosis risk. CD4

objectiveWe aim to identify CD4

methodsWe applied RNA sequencing on CD4

resultsWe did not identify significantly differentially expressed genes in CD4

conclusionWe conclude that CD4

Indexed as

CD4+ T cellsgene expressionGeneticsmultiple sclerosisRNA sequencing

Identifiers

PMID31223483
PMCPMC6566490
OpenAlexW2953033600

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.