ArticleBiochemia medica2019
European survey on preanalytical sample handling - Part 2: Practices of European laboratories on monitoring and processing haemolytic, icteric and lipemic samples. On behalf of the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Working Group for the Preanalytical Phase (WG-PRE).
Article in Biochemia medica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Development and Evaluation of Artificial Intelligence-Based Two-Step Model for Automated Serum Quality Assessment in Clinical Laboratories.Annals of laboratory medicine · 2026Article
- Optimization of icterus interference thresholds for 45 parameters on the Atellica analyzers CH930 and IM1300.Biochemia medica · 2026Article
- Lipemia and its associations with liver disease and dyslipidemia: a cross-sectional study.Lipids in health and disease · 2025Article
- How to handle lipemic CBC samples on Sysmex hematology analyzers?Advances in laboratory medicine · 2025Article
- Use of external quality assessment in extra-analytical phases in clinical laboratories in Spain: a survey by the Spanish Society of Laboratory Medicine (SEQCAdvances in laboratory medicine · 2025Article
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- Behind the scenes of EQA – characteristics, capabilities, benefits and assets of external quality assessment (EQA): Part I – EQA in general and EQA programs in particularClinical chemistry and laboratory medicine · 2025Review
- Knowledge among clinical personnel on the impact of hemolysis using blood gas analyzers.Clinical chemistry and laboratory medicine · 2025Article
- Evaluation of performance in preanalytical phase EQA: can laboratories mitigate common pitfalls?Clinical chemistry and laboratory medicine · 2025Article
- Preanalytical Errors in Clinical Laboratory Testing at a Glance: Source and Control Measures.Cureus · 2024Review
- Challenges of providing biochemistry results in a patient with Evans syndrome.Biochemia medica · 2024Review
- Frequency and types of pre-analytical errors in a clinical laboratory of a specialized healthcare hospital.Pakistan journal of medical sciences · 2024Article
- Charting the Next Road Map for CSF Biomarkers in Alzheimer's Disease and Related Dementias.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Review
- Evaluation of hemolysis, lipemia, and icterus interference with common clinical immunoassays.Clinical chemistry and laboratory medicine · 2023Article
- Handling of lipemic samples in the clinical laboratory.Advances in laboratory medicine · 2023Article
- Interferograms plotted with reference change value (RCV) may facilitate the management of hemolyzed samples.Journal of medical biochemistry · 2022Article
- Frequency of icteric interference in clinical chemistry laboratory tests and causes of severe icterus.Practical laboratory medicine · 2021Article
- Strawberry pink blood: hypertriglyceridaemia and diabetic ketoacidosis secondary to poorly controlled type 2 diabetes mellitus.BMJ case reports · 2021Article
- Delayed diagnosis and treatment of extreme hypertriglyceridemia due to rejection of a lipemic sample.Biochemia medica · 2021Article
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Authors and funding
14 authors.
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Abstract
introductionNo guideline currently exists on how to detect or document haemolysis, icterus or lipemia (HIL) in blood samples, nor on subsequent use of this information. The EFLM WG-PRE has performed a survey for assessing current practices of European laboratories in HIL monitoring. This second part of two coherent articles is focused on HIL. MATERIALS AND
methodsAn online survey, containing 39 questions on preanalytical issues, was disseminated among EFLM member countries. Seventeen questions exclusively focused on assessment, management and follow-up actions of HIL in routine blood samples.
resultsOverall, 1405 valid responses from 37 countries were received. A total of 1160 (86%) of all responders stating to analyse blood samples - monitored HIL. HIL was mostly checked in clinical chemistry samples and less frequently in those received for coagulation, therapeutic drug monitoring and serology/infectious disease testing. HIL detection by automatic HIL indices or visual inspection, along with haemolysis cut-offs definition, varied widely among responders. A quarter of responders performing automated HIL checks used internal quality controls. In haemolytic/icteric/lipemic samples, most responders (70%) only rejected HIL-sensitive parameters, whilst about 20% released all test results with general comments. Other responders did not analysed but rejected the entire sample, while some released all tests, without comments. Overall, 26% responders who monitored HIL were using this information for monitoring phlebotomy or sample transport quality.
conclusionStrategies for monitoring and treating haemolytic, icteric or lipemic samples are quite heterogeneous in Europe. The WG-PRE will use these insights for developing and providing recommendations aimed at harmonizing strategies across Europe.
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