Evidence map›Paper›PMID 31223258›Full record

ArticleBiochemia medica2019

European survey on preanalytical sample handling - Part 1: How do European laboratories monitor the preanalytical phase? On behalf of the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Working Group for the Preanalytical Phase (WG-PRE).

Janne Cadamuro, Giuseppe Lippi, Alexander von Meyer, Mercedes Ibarz, Edmee van Dongen, Lases5, Michael Cornes, Mads Nybo, Pieter Vermeersch, Kjell Grankvist and 4 more

Abstract read
In one paragraph

Article in Biochemia medica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Advances in laboratory medicine · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. [Pre-analytical quality assessment in the microbiology laboratory].Revista medica del Instituto Mexicano del Seguro Social · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Janne CadamuroDepartment of Laboratory Medicine, Paracelsus Medical University, Salzburg, Austria.
Giuseppe LippiSection of Clinical Chemistry, University of Verona, Verona, Italy.
Alexander von MeyerInstitute of Laboratory Medicine, Kliniken Nordoberpfalz AG and Klinikum St. Marien, Weiden and Amberg, Germany.
Mercedes IbarzDepartment of Laboratory Medicine, University Hospital Arnau de Vilanova, IRBLleida, Lleida, Spain.
Edmee van DongenDepartment of Laboratory Medicine, Paracelsus Medical University, Salzburg, Austria.
Lases5
Michael CornesClinical Chemistry Department, Worcestershire Acute Hospitals NHS Trust, Worcester, UK.
Mads NyboDepartment of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark.
Pieter VermeerschClinical Department of Laboratory Medicine, University Hospitals Leuven, Leuven, Belgium.
Kjell GrankvistDepartment of Medical Biosciences, Clinical Chemistry, Umea University, Umea, Sweden.
Joao Tiago GuimaraesDepartment of Clinical Pathology, São João Hospital Center, Department of Biomedicine, Faculty of Medicine, and EPI Unit, Institute of Public Health, University of Porto, Porto, Portugal.
Gunn B B KristensenNorwegian Quality Improvement of laboratory examinations (Noklus), Bergen, Norway.
Barbara de la SalleUK NEQAS Haematology, West Hertfordshire Hospitals NHS Trust, operating UK NEQAS for Haematology and Transfusion, Watford, UK.
Ana-Maria SimundicDepartment of Medical Laboratory Diagnostics, University Hospital Sveti Duh, Zagreb, Croatia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCompared to other activities of the testing process, the preanalytical phase is plagued by a lower degree of standardization, which makes it more vulnerable to errors. With the aim of providing guidelines and recommendations, the EFLM WG-PRE issued a survey across European medical laboratories, to gather information on local preanalytical practices. This is part one of two coherent articles, which covers all practices on monitoring preanalytical quality except haemolysis, icterus and lipemia (HIL). MATERIALS AND

methodsAn online survey, containing 39 questions dealing with a broad spectrum of preanalytical issues, was disseminated to EFLM member countries. The survey included questions on willingness of laboratories to engage in preanalytical issues.

resultsOverall, 1405 valid responses were received from 37 countries. 1265 (94%) responders declared to monitor preanalytical errors. Assessment, documentation and further use of this information varied widely among respondents and partially among countries. Many responders were interested in a preanalytical online platform, holding information on various aspects of the preanalytical phase (N = 1177; 87%), in a guideline for measurement and evaluation of preanalytical variables (N = 1235; 92%), and in preanalytical e-learning programs or webinars (N = 1125; 84%). Fewer responders were interested in, or already participating in, preanalytical EQA programs (N = 951; 71%).

conclusionAlthough substantial heterogeneity was found across European laboratories on preanalytical phase monitoring, the interest in preanalytical issues was high. A large majority of participants indicated an interest in new guidelines regarding preanalytical variables and learning activities. This important data will be used by the WG-PRE for providing recommendations on the most critical issues.

Indexed as

Clinical MedicinePre-Analytical PhaseSurveys and QuestionnairesChemistry, ClinicalClinical Laboratory TechniquesEuropeHumanspreanalyticsstandardizationsurvey

Identifiers

PMID31223258
PMCPMC6559617

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.