Evidence map›Paper›PMID 31223137›Full record

ArticleNeurobiology of pain (Cambridge, Mass.)

In search of a rodent model of placebo analgesia in chronic orofacial neuropathic pain.

Titilola Akintola, Christina Tricou, Charles Raver, Alberto Castro, Luana Colloca, Asaf Keller

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of pain (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. An Amygdalo-Parabrachial Pathway Regulates Pain Perception and Chronic Pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Titilola AkintolaDepartment of Pain and Translational Symptom Science, University of Maryland School of Nursing, Baltimore, MD, USA.
Christina TricouProgram in Neuroscience, University of Maryland School of Medicine, Baltimore, MD, USA.
Charles RaverDepartment of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Alberto CastroDepartment of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Luana CollocaDepartment of Pain and Translational Symptom Science, University of Maryland School of Nursing, Baltimore, MD, USA.
Asaf KellerCenter to Advance Chronic Pain Research, University of Maryland, Baltimore, MD, USA.
University of Maryland, Baltimore · US

Funding

Central mechanisms of maintenance of orofacial pain after injuryR01DE021804 · NIDCR · UNIVERSITY OF MARYLAND BALTIMORE · PI DUBNER, RONALD, KELLER, ASAF · 2011 to 2015
$3.2M
Serotonin and Pain ModulationR01NS104297 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI KELLER, ASAF, MASRI, RADI · 2019 to 2023
$2.4M
Parabrachial role in chronic painR01NS099245 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI KELLER, ASAF, MASRI, RADI · 2017 to 2021
$2.2M
Chronic orofacial pain: genetics, cognitive-emotional factors, and endogenous modulatory systemsR01DE025946 · NIDCR · UNIVERSITY OF MARYLAND BALTIMORE · PI COLLOCA, LUANA · 2016 to 2019
$2.1M
Cortical modulation of brainstem circuitsR01DE021735 · NIDCR · UNIVERSITY OF MARYLAND BALTIMORE · PI KELLER, ASAF · 2012 to 2016
$1.9M
NIDCR NIH HHS R01 DE021735NIDCR NIH HHS R01 DE021804NIDCR NIH HHS R01 DE025946NINDS NIH HHS R01 NS099245NINDS NIH HHS R01 NS104297
6 · The paper itself

Abstract

All treatments are given in a context, suggesting that conditioning cues may significantly influence therapeutic outcomes. We tested the hypothesis that context affects placebo analgesia in rodents. To produce neuropathic pain in rats, we performed chronic constriction injury of the infraorbital nerve. We then treated the rats daily, over a seven day period, with injections of either fentanyl or saline, with or without associated conditioning cues; a fourth group received no treatment. On the eighth day, we replaced fentanyl with saline to test for conditioned placebo analgesia. We tested the effects of treatment by measuring sensitivity to mechanical stimuli and grimace scale scores. We found no significant differences in either of these outcomes among the four experimental groups. These findings suggest that chronic, neuropathic pain in rats may not be susceptible to placebo analgesia.

Indexed as

AllodyniaConditioning effectsExpectancyFacial grimaceFentanylHyperalgesiaNeuropathic painOrofacial painPharmacological conditioning

Identifiers

PMID31223137
PMCPMC6565753
OpenAlexW2946329931

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.