Evidence map›Paper›PMID 31223062›Full record

ArticleEmerging microbes & infections2019

Cisplatin protects mice from challenge of

Zhong Li, Bin Fu, Cathleen M Green, Binbin Liu, Jing Zhang, Yuekun Lang, Sudha Chaturvedi, Marlene Belfort, Guojian Liao, Hongmin Li

Open access · goldAbstract read
In one paragraph

Article in Emerging microbes & infections, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Calcimycin InhibitsACS infectious diseases · 2022
    Article
  7. Journal of fungi (Basel, Switzerland) · 2022
    Article
  8. Article
  9. Inteins as Drug Targets and Therapeutic Tools.Frontiers in molecular biosciences · 2022
    Review
  10. Article
  11. Article
  12. Article
  13. Small-molecule inhibitors for the Prp8 intein as antifungal agents.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  14. Review
  15. Antifungal Drug Repurposing.Antibiotics (Basel, Switzerland) · 2020
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Zhong LiNew York State Department of Health , Wadsworth Center, Albany, NY, USA.ORCID 0000-0002-1039-7000
Bin FuCollege of Pharmaceutical Sciences, Southwest University, Chongqing, People's Republic of China.
Cathleen M GreenDepartment of Biological Sciences and RNA Institute, University at Albany, Albany, NY, USA.
Binbin LiuNew York State Department of Health , Wadsworth Center, Albany, NY, USA.
Jing ZhangNew York State Department of Health , Wadsworth Center, Albany, NY, USA.
Yuekun LangNew York State Department of Health , Wadsworth Center, Albany, NY, USA.
Sudha ChaturvediNew York State Department of Health , Wadsworth Center, Albany, NY, USA.
Marlene BelfortDepartment of Biological Sciences and RNA Institute, University at Albany, Albany, NY, USA.
Guojian LiaoCollege of Pharmaceutical Sciences, Southwest University, Chongqing, People's Republic of China.
Hongmin LiNew York State Department of Health , Wadsworth Center, Albany, NY, USA.ORCID 0000-0002-8684-5308
New York State Department of Health · USSouthwest University · CNUniversity at Albany, State University of New York · US

Funding

X-ray Absorption Spectroscopy (XAS) pp.711-759P41GM103393 · NIGMS · STANFORD UNIVERSITY · PI HODGSON, KEITH O · 2012 to 2019
$30.6M
SELF-SPLICING INTEINS: FUNCTION, EVOLUTION, APPLICATIONR01GM044844 · NIGMS · WADSWORTH CENTER · PI BELFORT, MARLENE · 1990 to 2019
$8.9M
SELF-SPLICING INTRONS IN THE PHAGE T4/E COLI SYSTEMR01GM039422 · NIGMS · WADSWORTH CENTER · PI BELFORT, MARLENE · 1988 to 2019
$5.3M
INTRON DYNAMICS IN BACTERIAR37GM039422 · NIGMS · WADSWORTH CENTER · PI BELFORT, MARLENE · 2001 to 2010
$4.0M
High throughput screening of the Prp8 intein splicing inhibitors for pathogenic fungiR01AI140726 · NIAID · WADSWORTH CENTER · PI LI, HONGMIN · 2019 to 2022
$2.4M
Discovery of therapeutics against Cryptococcosis by Repurposing Pharmaceutical LibrariesR21AI141178 · NIAID · WADSWORTH CENTER · PI LI, HONGMIN · 2019 to 2020
$441k
NIAID NIH HHS R01 AI140726NIAID NIH HHS R21 AI141178NIGMS NIH HHS P41 GM103393NIGMS NIH HHS R01 GM039422NIGMS NIH HHS R01 GM044844NIGMS NIH HHS R37 GM039422
6 · The paper itself

Abstract

The Prp8 intein is one of the most widespread eukaryotic inteins, present in important pathogenic fungi, including

Indexed as

InteinsAmino Acid SequenceAnimalsAntifungal AgentsCisplatinCryptococcosisCryptococcus neoformansFemaleFungal ProteinsHumansMiceMice, Inbred BALB CModels, MolecularRNA-Binding ProteinsSequence AlignmentAntifungal AgentsCisplatinFungal ProteinsRNA-Binding ProteinsantifungalCisplatinmouse modelPrp8 intein

Identifiers

PMID31223062
PMCPMC6598491
OpenAlexW2951874591

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.