ArticleJournal of biomedical optics2019
Plasmonic imaging of subcellular electromechanical deformation in mammalian cells.
Article in Journal of biomedical optics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The trial behind it
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Optical Detection of Cellular Signals at Material Interfaces.Advanced healthcare materials · 2026Review
- Spark or Sound: How Two Differing Explanatory Strategies Impact the Debate on the Physical Nature of Neuronal Excitability.Membranes · 2026Article
- Deep Learning Enhanced Label-Free Action Potential Detection Using Plasmonic-Based Electrochemical Impedance Microscopy.Analytical chemistry · 2024Article
- Optical Electrophysiology: Toward the Goal of Label-Free Voltage Imaging.Journal of the American Chemical Society · 2021Article
- On the Coupling between Mechanical Properties and Electrostatics in Biological Membranes.Membranes · 2021Review
- Optical Imaging of Electrical and Mechanical Couplings between Cells.ACS sensors · 2021Article
- Reply to Farrell: Experimental evidence is the ultimate judge for model assumptions.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- High-speed interferometric imaging reveals dynamics of neuronal deformation during the action potential.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Surface Plasmon Resonance Microscopy: From Single-Molecule Sensing to Single-Cell Imaging.Angewandte Chemie (International ed. in English) · 2020Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
A membrane potential change in cells is accompanied with mechanical deformation. This electromechanical response can play a significant role in regulating action potential in neurons and in controlling voltage-gated ion channels. However, measuring this subtle deformation in mammalian cells has been a difficult task. We show a plasmonic imaging method to image mechanical deformation in single cells upon a change in the membrane potential. Using this method, we have studied the electromechanical response in mammalian cells and have observed the local deformation within the cells that are associated with cell-substrate interactions. By analyzing frequency dependence of the response, we have further examined the electromechanical deformation in terms of mechanical properties of cytoplasm and cytoskeleton. We demonstrate a plasmonic imaging approach to quantify the electromechanical responses of single mammalian cells and determine local variability related to cell-substrate interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.