Evidence map›Paper›PMID 31222958›Full record

ArticleMaternal & child nutrition2019

Birth size and early pneumonia predict linear growth among HIV-exposed uninfected infants.

Emily L Deichsel, Patricia B Pavlinac, Barbra A Richardson, Dorothy Mbori-Ngacha, Judd L Walson, Christine J McGrath, Carey Farquhar, Rose Bosire, Elizabeth Maleche-Obimbo, Grace C John-Stewart

Open access · bronzeAbstract read
In one paragraph

Article in Maternal & child nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Emily L DeichselBiostatistics, Global Health, Epidemiology, Medicine, University of Washington, Seattle, Washington.ORCID 0000-0002-6172-9458
Patricia B PavlinacBiostatistics, Global Health, Epidemiology, Medicine, University of Washington, Seattle, Washington.
Barbra A RichardsonBiostatistics, Global Health, Epidemiology, Medicine, University of Washington, Seattle, Washington.
Dorothy Mbori-NgachaUnited Nations Children's Fund (UNICEF), New York, New York.
Judd L WalsonBiostatistics, Global Health, Epidemiology, Medicine, University of Washington, Seattle, Washington.
Christine J McGrathBiostatistics, Global Health, Epidemiology, Medicine, University of Washington, Seattle, Washington.
Carey FarquharBiostatistics, Global Health, Epidemiology, Medicine, University of Washington, Seattle, Washington.
Rose BosireCenter for Public Health Research, Kenya Medical Research Institute (KEMRI), Nairobi, Kenya.
Elizabeth Maleche-ObimboDepartment of Paediatrics ands Child Health, University of Nairobi, Nairobi, Kenya.
Grace C John-StewartBiostatistics, Global Health, Epidemiology, Medicine, University of Washington, Seattle, Washington.
University of Washington · USKenya Medical Research Institute · KEUnited Nations Children's Fund · USUniversity of Nairobi · KE

Funding

Understanding the pathway between maternal health and infant diarrhea, malnutrition, and death among HIV-exposed, uninfected childrenF31HD089507 · NICHD · UNIVERSITY OF WASHINGTON · PI DEICHSEL, EMILY · 2016 to 2017
$84k
NICHD NIH HHS F31 HD089507
6 · The paper itself

Abstract

Stunting remains a global health priority, particularly in sub-Saharan Africa. Identifying determinants of linear growth in HIV-exposed uninfected (HEU) infants can inform interventions to prevent stunting in this vulnerable population. HIV-infected mothers and their uninfected infants were followed monthly from pregnancy to 12-month post-partum in Nairobi, Kenya. Mixed-effects models estimated the change in length-for-age z-score (LAZ) from birth to 12 months by environmental, maternal, and infant characteristics. Multivariable models included factors univariately associated with LAZ. Among 372 HEU infants, mean LAZ decreased from -0.54 (95% confidence interval [CI] [-0.67, -0.41]) to -1.09 (95% CI [-1.23, -0.96]) between 0 and 12 months. Declines in LAZ were associated with crowding (≥2 persons per room; adjusted difference [AD] in 0-12 month change: -0.46; 95% CI [-0.87, -0.05]), use of a pit latrine versus a flush toilet (AD: -0.29; 95% CI [-0.57, -0.02]), and early infant pneumonia (AD: -1.14; 95% CI [-1.99, -0.29]). Infants with low birthweight (<2,500 g; AD: 1.08; 95% CI [0.40, 1.76]) and birth stunting (AD: 1.11; 95% CI [0.45, 1.78]) experienced improved linear growth. By 12 months of age, 46 infants were stunted, of whom 11 (24%) were stunted at birth. Of the 34 infants stunted at birth with an available 12-month LAZ, 68% were not stunted at 12 months. Some low birthweight and birth-stunted HEU infants had significant linear growth recovery. Early infant pneumonia and household environment predicted poor linear growth and may identify a subgroup of HEU infants for whom to provide growth-promoting interventions.

Indexed as

Infant, Newborn, DiseasesPneumoniaAdultBirth WeightChild DevelopmentCohort StudiesFemaleGrowth DisordersHIV InfectionsHumansInfant, NewbornKenyaPregnancyPregnancy Complications, InfectiousResidence CharacteristicsSocioeconomic FactorsHIV exposed uninfectedinfant linear growthKenyalow birthweightpneumonia

Identifiers

PMID31222958
PMCPMC6859978
OpenAlexW2950613181

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.