ArticleHuman brain mapping2019
Associations between brain morphology and motor performance in chronic neck pain: A whole-brain surface-based morphometry approach.
Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Brain morphometric alterations associated with degenerative scoliosis: a structural MRI study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Clinical significance of exercise-induced hypoalgesia in individuals with temporomandibular disorders and neck pain: A clinical trial protocol.Experimental physiology · 2026Article
- Association of brain cortical changes with efficacy of treatment in patients with chronic neck and shoulder pain: a longitudinal surface-based morphometry study.Frontiers in neuroscience · 2026Article
- Altered Cortical Structure in Primary Dysmenorrhea: Cortical Thickness Mediates the Association Between Estradiol and Pain Catastrophizing.Journal of pain research · 2026Article
- Changes in cerebral cortex activation during upright standing tasks in individuals with chronic neck pain: an fNIRS study.Frontiers in neurology · 2025Article
- Cross-Cultural Adaptation, Reliability, and Validity of the Greek Version of the Fremantle Neck Awareness Questionnaire (FreNAQ-GR) in Patients with Chronic Neck Pain.Healthcare (Basel, Switzerland) · 2024Article
- Article
- Alteration of the cortical morphology in classical trigeminal neuralgia: voxel-, deformation-, and surface-based analysis.The journal of headache and pain · 2023Article
- Characterization of spatiotemporal dynamics of binary and graded tonic pain in humans using intracranial recordings.PloS one · 2023Article
- Identifying the neural marker of chronic sciatica using multimodal neuroimaging and machine learning analyses.Frontiers in neuroscience · 2022Article
- Structural and Functional Asymmetry in Precentral and Postcentral Gyrus in Patients With Unilateral Chronic Shoulder Pain.Frontiers in neurology · 2022Article
- Effects of Sub-threshold Transcutaneous Auricular Vagus Nerve Stimulation on Cingulate Cortex and Insula Resting-state Functional Connectivity.Frontiers in human neuroscience · 2022Article
- Dynamic alterations of amplitude of low-frequency fluctuations in patients with chronic neck pain.Psychoradiology · 2021Article
- Early alterations of cortical thickness and gyrification in migraine without aura: a retrospective MRI study in pediatric patients.The journal of headache and pain · 2021Article
- Enhanced amygdala-frontal operculum functional connectivity during rest in women with chronic neck pain: Associations with impaired conditioned pain modulation.NeuroImage. Clinical · 2021Article
- Structural neuroimaging findings in migraine patients with restless legs syndrome.Neuroradiology · 2020Article
- Does Motor Cortex Engagement During Movement Preparation Differentially Inhibit Nociceptive Processing in Patients with Chronic Whiplash Associated Disorders, Chronic Fatigue Syndrome and Healthy Controls? An Experimental Study.Journal of clinical medicine · 2020Article
- Altered intrinsic brain activity and regional cerebral blood flow in patients with chronic neck and shoulder pain.Polish journal of radiology · 2020Article
- Cerebral Blood Flow and Its Connectivity Deficits in Mild Traumatic Brain Injury at the Acute Stage.Neural plasticity · 2020Article
- Associations between brain morphology and motor performance in chronic neck pain: A whole-brain surface-based morphometry approach.Human brain mapping · 2019Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Changes in brain morphology are hypothesized to be an underlying process that drive the widespread pain and motor impairment in patients with chronic neck pain. However, no earlier research assessed whole-brain cortical morphology in these patients. This case-control study assesses group-differences in whole-brain morphology between female healthy controls (HC; n = 34), and female patients with chronic idiopathic neck pain (CINP; n = 37) and whiplash-associated disorders (CWAD; n = 39). Additionally, the associations between whole-brain morphology and motor performance including balance, strength, and neuromuscular control were assessed. Cortical volume, thickness, and surface area were derived from high resolution T1-weighted images. T2*-weighted images were obtained to exclude traumatic brain injury. Vertex-wise general-linear-model-analysis revealed cortical thickening in the left precuneus and increased volume in the left superior parietal gyrus of patients with CINP compared to HC, and cortical thickening of the left superior parietal gyrus compared to HC and CWAD. Patients with CWAD showed a smaller cortical volume in the right precentral and superior temporal gyrus compared to HC. ANCOVA-analysis revealed worse neuromuscular control in CWAD compared to HC and CINP, and in CINP compared to HC. Patients with CWAD showed decreased levels of strength and sway area compared to CINP and HC. Partial correlation analysis revealed significant associations between the volume of the precentral gyrus, and neuromuscular control and strength together with an association between the volume of the superior temporal gyrus and strength. Our results emphasize the role of altered gray matter alterations in women with chronic neck pain, and its association with pain and motor impairment.
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