Trial reportJournal of cosmetic dermatology2020
A cosmetic treatment based on the secretion of Cryptomphalus aspersa 40% improves the clinical results after the use of nonablative fractional laser in skin aging.
Trial report in Journal of cosmetic dermatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Early and maintained application of the secretion of Cryptomphalus aspersa (SCA) 40% improves cutaneous healing after ablative fractional laser in skin aging.Journal of cosmetic dermatology · 2021Trial
- A cosmetic treatment based on the secretion of Cryptomphalus aspersa 40% improves the clinical results after the use of nonablative fractional laser in skin aging.Journal of cosmetic dermatology · 2020Trial
- Preventive and Therapeutic Interventions in Solar Elastosis and Photoaging: A Comprehensive Systematic Review.Biomedicines · 2025Review
- Prevention of radiation induced dermatitis in head and neck cancer patients using cryptomphalus aspersa secretion.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Article
- Chemical composition, mineral profile, anti-bacterial, and wound healing properties of snail slime ofBioMedicine · 2023Article
- Snail mucus from the mantle and foot of two land snails, Lissachatina fulica and Hemiplecta distincta, exhibits different protein profile and biological activity.BMC research notes · 2021Article
- Longitudinal monitoring and prediction of long-term outcome of scar stiffness on pediatric patients.Burns & trauma · 2021Article
- EGR1 Is a Critical Gene in Response of Human Keratinocyte to Blue Light Radiation.Journal of lasers in medical sciences · 2021Article
- Efficacy and Safety of a New Cosmeceutical Regimen Based on the Combination of Snail Secretion Filtrate and Snail Egg Extract to Improve Signs of Skin Aging.The Journal of clinical and aesthetic dermatology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
introductionThe main purpose of this study was to evaluate whether the application of a cosmetic treatment based on the secretion of Cryptomphalus aspersa (SCA) enhances the clinical results, tolerance, and skin regeneration after nonablative laser treatment in patients with moderate photoaging.
methodsRandomized, double-blind, split-face trial in 20 patients with moderate aging. Two sessions with fractional nonablative laser were performed, and the cosmetic treatments (SCA 40% on one hemiface and vehicle on the other) were applied immediately after laser session and daily during the study (28 days). Tewameter, Cutometer, Visioscan, VisioFace, photography, dermoscopy, and clinical evaluation were assessed. Side effects were also evaluated.
resultsA significant decrease in the density of microcolumns (25%, 71%, 32%, and 61% less density, respectively, at T3 P = 0.008, T7 P = 0.002, T22 P < 0.001, and T24 P < 0.001) was observed on the side treated with SCA compared to the vehicle-treated side. Cutaneous elasticity, area of wrinkles, and hydration on the SCA-treated side also showed a significant improvement compared to the vehicle-treated side. Both the researcher and patients observed a significant improvement on the side treated with SCA compared to the vehicle-treated side. Significantly fewer side effects (erythema, burning, and dryness) were also detected.
conclusionA cosmetic product with SCA 40% applied immediately after laser and for a period thereafter enhances and accelerates repair of damage produced by the laser and significantly reduces related adverse effects. In addition, SCA treatment could improve clinical results. In conclusion, we suggest that SCA enhances the effectiveness of laser in the treatment of cutaneous aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.