Evidence map›Paper›PMID 31222775›Full record

Observational studyTransfusion2019

Implementation of a patient blood management program in hematopoietic stem cell transplantation (Editorial, p. 2763).

Matthew A Warner, Nilesh S Jambhekar, Salwa Saadeh, Eapen K Jacob, Justin D Kreuter, William C Mundell, Alberto Marquez, Andrew A Higgins, Nageswar R Madde, William J Hogan and 1 more

Open access · greenAbstract readObservational Study
In one paragraph

Observational study in Transfusion, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Impact of Shelf-Life Extension on Platelet Availability: Results from an Inventory Management Modeling Study.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2024
    Article
  3. Article
  4. Review
  5. Observational
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Matthew A WarnerDepartment of Anesthesiology & Perioperative Medicine, Mayo Clinic, Rochester, Minnesota.ORCID 0000-0002-6625-8755
Nilesh S JambhekarDepartment of Anesthesiology & Perioperative Medicine, Mayo Clinic, Rochester, Minnesota.
Salwa SaadehDivision of Hematology, Mayo Clinic, Rochester, Minnesota.
Eapen K JacobDivision of Transfusion Medicine, Mayo Clinic, Rochester, Minnesota.
Justin D KreuterDivision of Transfusion Medicine, Mayo Clinic, Rochester, Minnesota.
William C MundellDivision of Hospital Internal Medicine, Mayo Clinic, Rochester, Minnesota.
Alberto MarquezDepartment of Anesthesiology & Perioperative Medicine, Mayo Clinic, Rochester, Minnesota.
Andrew A HigginsDepartment of Anesthesiology & Perioperative Medicine, Mayo Clinic, Rochester, Minnesota.
Nageswar R MaddeDepartment of Anesthesiology & Perioperative Medicine, Mayo Clinic, Rochester, Minnesota.
William J HoganDivision of Hematology, Mayo Clinic, Rochester, Minnesota.
Daryl J KorDepartment of Anesthesiology & Perioperative Medicine, Mayo Clinic, Rochester, Minnesota.
Mayo Clinic · US

Funding

ZESTRIL VS. VERAPAMIL IN THE TREATMENT OF HYPERTENSIONM01RR000585 · NCRR · MAYO CLINIC ROCHESTER · PI RIZZA, ROBERT A. · 1985 to 2006
$30.4M
Institutional Career Development CoreKL2TR002379 · NCATS · MAYO CLINIC ROCHESTER · PI NILUFER ERTEKIN-TANER · 2017 to 2026
$14.9M
Point-of-Care RBC Washing to Prevent Transfusion-Related Pulmonary ComplicationsR01HL121232 · NHLBI · MAYO CLINIC ROCHESTER · PI KOR, DARYL J, WELSBY, IAN J · 2014 to 2018
$3.2M
NCATS NIH HHS KL2 TR002379NCRR NIH HHS M01 RR000585NHLBI NIH HHS R01 HL121232NIH HHS R01 HL121232
6 · The paper itself

Abstract

backgroundRecipients of hematopoietic stem cell transplantation (HSCT) are among the highest consumers of allogeneic red blood cell (RBC) and platelet (PLT) components. The impact of patient blood management (PBM) efforts on HSCT recipients is poorly understood. STUDY DESIGN AND

methodsThis observational study assessed changes in blood product use and patient-centered outcomes before and after implementing a multidisciplinary PBM program for patients undergoing HSCT at a large academic medical center. The pre-PBM cohort was treated from January 1 through September 31, 2013; the post-PBM cohort was treated from January 1 through September 31, 2015.

resultsWe identified 708 patients; 284 of 352 (80.7%) in the pre-PBM group and 225 of 356 (63.2%) in the post-PBM group received allogeneic RBCs (p < 0.001). Median (interquartile range [IQR]) RBC volumes were higher before PBM than after PBM (3 [2-4] units vs. 2 [1-4] units; p = 0.004). A total of 259 of 284 pre-PBM patients (91.2%) and 57 of 225 (25.3%) post-PBM patients received RBC transfusions when hemoglobin levels were more than 7 g/dL (p < 0.001). The median (IQR) PLT transfusion quantities was 3 (2-5) units for pre-PBM patients and 2 (1-4) units for post-PBM patients (p < 0.001). For patients with PLT counts of more than 10 × 10

conclusionPatient blood management implementation for HSCT recipients was associated with marked reductions in allogeneic RBC and PLT transfusions and decreased transfusion-related costs with no detrimental impact on clinical outcomes.

Indexed as

Blood SafetyHealth Plan ImplementationHematopoietic Stem Cell TransplantationAgedCost-Benefit AnalysisErythrocyte TransfusionFemaleHumansMaleMiddle AgedPatient AdmissionPatient Outcome AssessmentPatient ReadmissionPatient SafetyPlatelet TransfusionProgram Evaluation

Identifiers

PMID31222775
PMCPMC6813829
OpenAlexW2949284285

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.