Evidence map›Paper›PMID 31222597›Full record

ArticleMaternal and child health journal2019

Early Autism Spectrum Disorders in Children Born to Fertile, Subfertile, and ART-Treated Women.

Hafsatou Diop, Howard Cabral, Daksha Gopal, Xiaohui Cui, Judy E Stern, Milton Kotelchuck

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Maternal and child health journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
5.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Pooled it
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  11. Assisted reproductive technology: Short- and long-term outcomes.Developmental medicine and child neurology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Hafsatou DiopMassachusetts Department of Public Health, 250 Washington Street, 6th Floor, Boston, MA, 02108, USA. Hafsatou.Diop@state.ma.us.ORCID http://orcid.org/0000-0002-3654-9674
Howard CabralDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Daksha GopalDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Xiaohui CuiMassachusetts Department of Public Health, 250 Washington Street, 6th Floor, Boston, MA, 02108, USA.
Judy E SternObstetrics and Gynecology and Pathology, Dartmouth-Hitchcock, Lebanon, NH, USA.
Milton KotelchuckDivision of General Academic Pediatrics/Center for Child and Adolescent Health Research & Policy, MassGeneral Hospital for Children and Harvard Medical School, Boston, MA, USA.
Boston University · USMassachusetts Department of Public Health · USDartmouth–Hitchcock Medical Center · USHarvard University · US

Funding

Women's Health After Assisted Reproductive Technology: A Population-Based StudyR01HD067270 · NICHD · DARTMOUTH-HITCHCOCK CLINIC · PI DIOP, HAFSATOU, STERN, JUDY E · 2011 to 2020
$7.4M
Child Health After Assisted Reproductive Technology: A Population-Based StudyR01HD064595 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI DECLERCQ, EUGENE R, DIOP, HAFSATOU · 2010 to 2014
$3.1M
NICHD NIH HHS R01 HD064595NICHD NIH HHS R01 HD067270NIH HHS 5RO1HD067270-07
6 · The paper itself

Abstract

introductionWe examined the prevalence of autism spectrum disorders (ASDs) in Massachusetts (MA) comparing children born via assisted reproductive technology (ART) and children born to women with indicators of subfertility but no ART (Subfertile), to children born to women with neither ART nor indicators of subfertility (Fertile). We assessed the direct, indirect, and total effects of ART and subfertility on ASD among singletons.

methodsThis study included 10,147 ART, 8072 Subfertile and 441,898 Fertile MA resident births from the MA Outcome Study of ART (MOSART) database linked with Early Intervention program participation data. ART included fresh in vitro fertilization (IVF), fresh intracytoplasmic sperm injection (ICSI), and frozen embryo transfer. We estimated the prevalence of ASD by fertility group. We used logistic regression to assess the natural direct effect (NDE), natural indirect effect (NIE) through preterm birth, and total effects of each fertility group on ASD.

resultsThe NDE indicated that, compared to the Fertile group, the odds of ASD were not statistically higher in the ART (OR

conclusionCompared to children born to Fertile women, children born to ART, ICSI, or IVF, or Subfertile women are not at increased risk of receiving an ASD diagnosis.

Indexed as

AdultAutism Spectrum DisorderCohort StudiesFemaleFertilityHumansInfantInfant, NewbornInfertilityLongitudinal StudiesMassachusettsPregnancyPremature BirthReproductive Techniques, AssistedAssisted reproductive technologyAutism spectrum disordersIntracytoplasmic sperm injectionIn vitro fertilizationMOSARTSubfertile

Identifiers

PMID31222597
PMCPMC7012189
OpenAlexW2950471691

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.