ArticleDiabetes therapy : research, treatment and education of diabetes and related disorders2019
Insulin-Related Lipohypertrophy in Hemodialyzed Diabetic People: a Multicenter Observational Study and a Methodological Approach.
Article in Diabetes therapy : research, treatment and education of diabetes and related disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 22 citations in OpenAlex.
- The Economic Burden of Insulin Injection-Induced Lipohypertophy. Role of Education: The ISTERP-3 Study.Advances in therapy · 2022Trial
- Development of a diagnostic model of insulin-related lipohypertrophy for patients with diabetes mellitus.Journal of diabetes investigation · 2025Article
- Health-Economic Modelling of Improved Behavior in Insulin Injection Technique in Belgium.PharmacoEconomics - open · 2025Article
- Article
- A Hypothesis on the Progression of Insulin-Induced Lipohypertrophy: An Integrated Result of High-Frequency Ultrasound Imaging and Blood Glucose Control of Patients.Diagnostics (Basel, Switzerland) · 2023Article
- The Role of the Person Focused IARA Model in Reducing Anxiety and Improving Body Awareness and Illness Management in Diabetics with Acquired Lipodystrophy: A Mixed-Method Study.Journal of personalized medicine · 2022Article
- Leveraging Mechanical Forces to Target Insulin Injection-Induced Lipohypertrophy and Fibrosis.Diabetes spectrum : a publication of the American Diabetes Association · 2021Article
- Role of Structured Education in Reducing Lypodistrophy and its Metabolic Complications in Insulin-Treated People with Type 2 Diabetes: A Randomized Multicenter Case-Control Study.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2021Article
- Lipohypertrophy in Elderly Insulin-Treated Patients With Type 2 Diabetes.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2021Review
- Flash Glucose Monitoring to Assess Glycemic Control and Variability in Hemodialysis Patients: The GIOTTO Study.Frontiers in medicine · 2021Article
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7 authors at 1 institution in 1 country.
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Abstract
introductionEnd-stage renal disease (ESRD) is associated with increased cardiovascular mortality (CVM) and diabetes mellitus (DM), which in many cases is treated with insulin. Skin lipohypertrophy (LH) very often occurs in insulin-treated (IT) patients as a consequence of inadequate injection technique and is one of the most prominent contributors to hypoglycemia (HYPO), glycemic variability (GV), and poor metabolic control (PMC).
methodThe aim of our multicenter observational study was to assess LH prevalence at self-injection sites and any possible factors predicting high LH/HYPO rates and GV in 296 dialyzed ITDM patients characterized by 64 ± 7 years of age, 7 ± 2 years disease duration, 2.6 ± 2.2 years dialysis duration, preferred pen utilization (80%), and basal-bolus regimen (87.4%) with self-injections (62.6%) largely surpassing caregiver-assisted ones (16.9%), and a mix of the two injection methods (20.5%).
resultsLH was detected in 57% of patients. Univariate analysis followed by backwards stepwise multivariate logistic regression function showed increased odds for developing LH in patients characterized by needle reuse, smaller injection areas, missed injection site rotation, higher HbA1c levels, and more prominent rates of HYPO and GV.
conclusionThis was the first time such observation was made. It is now time for further studies aimed at providing evidence also in ESRD ITDM patients for the cause-effect relationship among wrong injection behavior, LH, and poor metabolic control and for the long-term preventative role of suitable educational countermeasures.
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