Evidence map›Paper›PMID 31222592›Full record

ArticleDiabetes therapy : research, treatment and education of diabetes and related disorders2019

Influence of Supervised Disease Understanding and Diabetes Self-Management on Adherence to Oral Glucose-Lowering Treatment in Patients with Type 2 Diabetes.

John Doupis, Theodoros Alexandrides, Moses Elisaf, Andreas Melidonis, Stavros Bousboulas, Anastasia Thanopoulou, Emmanouil M Pagkalos, Iakovos Avramidis, Angelos Pappas, Eleni Arvaniti and 3 more

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Article in Diabetes therapy : research, treatment and education of diabetes and related disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

John DoupisInternal Medicine and Diabetes Department, NS Naval Hospital, Athens, Greece. john.doupis@joslin.harvard.edu.
Theodoros AlexandridesDivision of Endocrinology, Department of Medicine, University General Hospital of Patras, Patras, Greece.
Moses ElisafSchool of Health Sciences, Faculty of Medicine, Department of Internal Medicine, University of Ioannina, Ioannina, Greece.
Andreas MelidonisDiabetic Center, General Hospital "Tzanio", Piraeus, Greece.
Stavros BousboulasDiabetic Center, General Hospital "Ag. Panteleimon", Piraeus, Greece.
Anastasia ThanopoulouDiabetes Center, 2nd Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Hippokratio General Hospital, Athens, Greece.
Emmanouil M PagkalosDiabetes Department, Thermi Clinic, Thessaloniki, Greece.
Iakovos AvramidisFirst Medical Department, G. Papanikolaou General Hospital, Thessaloniki, Greece.
Angelos PappasDiabetic Center, Venizelio General Hospital Heraklion, Crete, Greece.
Eleni ArvanitiGeneral Hospital of Ioannina "G. Hatzikosta", Ioannina, Greece.
Eugenia KaramousouliMSD, Athens, Greece.
Bernd VossMSD RBSC GmbH, Haar, Germany.
Nikolaos Tentolouris1st Department of Propaedeutic Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSystematic patient education has been reported to improve adherence to treatment, leading to better clinical outcomes. This cluster randomized real-world study investigated the effect of a systematic education program and telephone support on self-reported adherence to oral glucose-lowering treatment in patients with type 2 diabetes mellitus (T2DM).

methodsCenters were randomized (1:1) to provide either standard-of-care (control group) or standard-of-care along with the education program and telephone support (empowerment group). Adherence to treatment and satisfaction with treatment were assessed using the four-item Morisky Medication Adherence Scale (MMAS-4) and the Diabetes Treatment Satisfaction Questionnaire (DTSQ). The study population included 457 patients (258/199 male/female) with T2DM and non-optimal glycemic control, on oral antidiabetic treatment (age 62.7 [11.4]; disease duration 8.5 [6.5] years).

resultsMMAS-4 high adherence rates for the control and empowerment groups were increased by 3.8% and 16.8% at 4 months (Breslow-Day test p = 0.04) and by 8.5% and 18.8% at 8 months of follow-up, respectively (Breslow-Day test p = 0.09), compared to baseline. Intense physical activity was increased in both control and empowerment groups by 2.3% and 13.9% at 4 months (Breslow-Day test p = 0.082) and by 4.0% and 22.5% at 8 months of follow-up (Breslow-Day test p < 0.001). Baseline mean (SD) HbA1c was significantly lower in the control group compared with the empowerment group [7.7% versus 8.0%, p = 0.001] and decreased in both groups at 4 months by 0.7% and 0.9%, respectively. The change from baseline in the mean DTSQ status score at 4 months was greater in the empowerment group, and the effect was sustained at 8 months (control group: 29.1, 30.5, and 30.9; empowerment group: 25.0, 28.7, and 29.4 at baseline, 4 and 8 months, respectively, p < 0.001).

conclusionSystematic education combined with telephone support delivered by physicians might be associated with improvement in treatment adherence and treatment satisfaction in patients with T2DM.

fundingMSD, Greece.

Indexed as

Oral glucose-lowering agentsSystematic education programTelephone supportTreatment adherenceTreatment satisfactionType 2 diabetes

Identifiers

PMID31222592
PMCPMC6612340

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.