ArticleInternational journal of legal medicine2019
Immunohistochemical expression of P-selectin, SP-A, HSP70, aquaporin 5, and fibronectin in saltwater drowning and freshwater drowning.
Article in International journal of legal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Application of Aquaporins as Markers in Forensic Pathology: A Systematic Review of the Literature.International journal of molecular sciences · 2024Pooled it
- Immunohistochemical cerebral cortex expression of aquaporin 4, aquaporin 5, aquaporin 9 Vasopressin and GFAP in saltwater drowning and freshwater drowning.International journal of legal medicine · 2026Article
- The diatom test for drowning: an unreported source of diatom contamination.International journal of legal medicine · 2025Article
- DNA forensics at forty: the way forward.International journal of legal medicine · 2025Review
- Oxidative stress and NF-KB/iNOS inflammatory pathway as innovative biomarkers for diagnosis of drowning and differentiating it from postmortem submersion in both fresh and saltwater in rats.International journal of legal medicine · 2024Article
- Relationship between intrathrombotic appearance of HSP27 and HSP70 and thrombus ages in a murine model of deep vein thrombosis.Scientific reports · 2023Article
- Forensic Diagnosis of Freshwater or Saltwater Drowning Using the Marker Aquaporin 5: An Immunohistochemical Study.Medicina (Kaunas, Lithuania) · 2022Article
- Acute or chronic pulmonary emphysema? Or both?-A contribution to the diagnosis of death due to violent asphyxiation in cases with pre-existing chronic emphysema.International journal of legal medicine · 2022Article
- Commentary on "Macromorphological findings in cases of death in water: a critical view on drowning signs".International journal of legal medicine · 2021Article
- Mini Review: The Forensic Value of Heat Shock Proteins.Frontiers in medicine · 2021Review
- Mini Review: Forensic Value of Aquaporines.Frontiers in medicine · 2021Review
- Membrane Attack Complex in Myocardial Ischemia/Reperfusion Injury: A Systematic Review for Post Mortem Applications.Diagnostics (Basel, Switzerland) · 2020Review
- Proteomics in Deaths by Drowning: Diagnostic Efficacy of Apolipoprotein A1 and α-1Antitrypsin, Pilot Study.Diagnostics (Basel, Switzerland) · 2020Article
- Immunohistochemical renal expression of aquaporin 2, arginine-vasopressin, vasopressin receptor 2, and renin in saltwater drowning and freshwater drowning.International journal of legal medicine · 2020Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The diagnosis of drowning is one of the most difficult in forensic medicine. The aim of this study was to analyze pulmonary tissue reactions in death by drowning. In particular, we focused on the immunohistochemical expression of P-selectin, SP-A, HSP70, AQP-5, and fibronectin to investigate our expression in drowning and to understand whether there are differences between saltwater drowning (SWD) and freshwater drowning (FWD), which may indicate a different pathophysiology. We retrospectively investigated 10 cases of SWD (Mediterranean Sea) from the Institute of Legal Medicine of Genoa (Italy), and 10 cases of FWD (Lake of Geneva) from the University Center of Legal Medicine of Geneva (Switzerland). As control group, we examined 10 cases of death by acute external bleeding, characterized by minimal respiratory distress. As compared with controls, in SWD cases, the results showed a decrease of SP-A expression with membrane patterns. Furthermore, we observed a greater SP-A expression with granular pattern in drowning cases without statistically significant difference between SWD and FWD. For the markers AQP-5, HSP70, fibronectin, and P-selectin, no statistically significant differences were found between SWD, FWD, and controls.
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