ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2021
Quantification of myocardial flow reserve using a gamma camera with solid-state cadmium-zinc-telluride detectors: Relation to angiographic coronary artery disease.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 68 citations in OpenAlex.
- The prognostic value of multiparameters derived from D-SPECT in patients with ANOCA.Annals of nuclear medicine · 2026Article
- Associations of AI-derived coronary CT angiography features with CZT-SPECT coronary flow reserve and FFR-CT.Frontiers in cardiovascular medicine · 2026Article
- Diagnostic and prognostic value of myocardial flow reserve quantification with single photon emission computed tomography - a systematic review and meta-analysis.EJNMMI research · 2025Article
- Comparison of global and regional myocardial blood flow quantification using dynamic solid-state detector SPECT and Tc-99 m-sestamibi or Tc-99 m-tetrofosmin in a routine clinical setting.The international journal of cardiovascular imaging · 2025Article
- Recent Progress in Myocardial Perfusion Imaging Techniques.Nuclear medicine and molecular imaging · 2024Review
- The Influence of Kinetic Models and Attenuation Correction on Cadmium-Zinc-Telluride Single-Photon Emission Computed Tomography (CZT SPECT)-Derived Myocardial Blood Flow and Reserve: Correlation with Invasive Angiography Data.Journal of clinical medicine · 2024Article
- Clinical Impact of Assessment of Myocardial Flow Reserve in Identifying the Cause of Chest Discomfort.Arquivos brasileiros de cardiologia · 2024Article
- Association between CZT‑SPECT myocardial blood flow and coronary stenosis: A cross‑sectional study.Experimental and therapeutic medicine · 2023Article
- Diagnostic value of quantitative myocardial blood flow assessment by NaI(Tl) SPECT in detecting significant stenosis: a prospective, multi-center study.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Accuracy and Reproducibility of Myocardial Blood Flow Quantification by Single Photon Emission Computed Tomography Imaging in Patients With Known or Suspected Coronary Artery Disease.Circulation. Cardiovascular imaging · 2022Article
- Myocardial blood flow quantitation with the SPECT technique: Where do we stand?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Myocardial Blood Flow and Flow Reserve in Patients With Acute Myocardial Infarction and Obstructive and Non-Obstructive Coronary Arteries: CZT SPECT Study.Frontiers in nuclear medicine · 2022Article
- Improved detection of coronary artery disease by CZT regional coronary blood flow evaluation.Frontiers in nuclear medicine · 2022Article
- A study protocol for an observational cohort investigating cardiac transthyretin amyloidosis flow reserve before and after Tafamidis treatment: The AMYTRE study.Frontiers in medicine · 2022Article
- Quantification of myocardial perfusion reserve by CZT-SPECT: A head to head comparison withJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Myocardial blood flow reserve and absolute myocardial blood flow for the assessment of patients with coronary artery disease with or without microvascular dysfunction.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Impact of attenuation correction for CZT-SPECT measurement of myocardial blood flow.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Capabilities of Modern Semiconductor Gamma Cameras in Radionuclide Diagnosis of Coronary Artery Disease.Diagnostics (Basel, Switzerland) · 2021Review
- A big step towards clinical implementation of myocardial blood flow quantification with CZT SPECT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Cardiac PET imaging: Lost in quantification. It's time to find the way.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies have suggested using gamma cameras with cadmium-zinc-telluride (CZT) detectors to quantify myocardial blood flow (MBF) and flow reserve (MFR). In this study, we aimed to evaluate the feasibility and accuracy of MFR quantification using a CZT camera compared to coronary angiography.
methodsForty-one participants referred for coronary angiography underwent a rest/stress one-day myocardial perfusion imaging protocol using a CZT gamma camera. Rest and stress dynamic phases were followed by acquisition of traditional perfusion images and time-activity curves were generated. Angiographic and perfusion results were compared to MFR.
resultsPatients with abnormal perfusion presented reduced MFR (2.01 [1.48-2.77] vs. 2.94 [2.38-3.64], P = 0.002), and reduced stress MBF. Patients with high-risk CAD had lower global MFR compared to patients without obstructive disease (1.99 [1.22-2.84] vs. 2.89 [2.22-3.58], P = 0.026). Obstructed vessels showed lower regional MFR when compared to non-obstructed (1.81 [1.19-2.67] vs. 2.75 [2.13-3.42], P < 0.001). A regional MFR of 2.2 provided a sensitivity of 63.2% and specificity of 74.1% to identify an obstructive lesion in the corresponding artery.
conclusionIn patients undergoing invasive coronary angiography for the evaluation of CAD, quantifying MBF and MFR in a CZT gamma camera is feasible and reflects underlying disease. In these patients, reduced regional MFR suggests the presence of obstructive lesion(s).
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