ArticleVeterinary research communications2019
Prevalence of Mycobacterium bovis infection in traditionally managed cattle at the wildlife-livestock interface in South Africa in the absence of control measures.
Article in Veterinary research communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Global prevalence and risk factors of bovine tuberculosis in cattle: a systematic review and meta-analysis.Frontiers in veterinary science · 2026Pooled it
- Prevalence of tuberculosis in bovines in Pakistan during 2000-2024: a systematic review and meta-analysis.Frontiers in veterinary science · 2025Pooled it
- Whole-genome sequencing reveals genetic diversity and transmission dynamics ofMicrobial genomics · 2026Article
- Challenge Dose Titration in aInternational journal of molecular sciences · 2024Article
- Seroprevalence and risk factors associated with bovine tuberculosis in cattle in Eastern Bhutan.PLoS neglected tropical diseases · 2024Article
- Absence of Tuberculosis-CausingInternational journal of microbiology · 2024Article
- Will we ever eradicate animal tuberculosis?Irish veterinary journal · 2023Article
- Challenges to the control of Mycobacterium bovis in livestock and wildlife populations in the South African context.Irish veterinary journal · 2023Article
- Advancing animal tuberculosis surveillance using culture-independent long-read whole-genome sequencing.Frontiers in microbiology · 2023Article
- Application of the gamma-interferon assay to determine the prevalence of bovine tuberculosis in slaughter livestock at abattoirs in Gauteng, South Africa.Veterinary medicine and science · 2022Article
- Improved detection ofJournal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2022Article
- Microbial Safety of Milk Production and Fermented Dairy Products in Africa.Microorganisms · 2020Review
- Tracing cross species transmission of Mycobacterium bovis at the wildlife/livestock interface in South Africa.BMC microbiology · 2020Article
- Risk practices for bovine tuberculosis transmission to cattle and livestock farming communities living at wildlife-livestock-human interface in northern KwaZulu Natal, South Africa.PLoS neglected tropical diseases · 2020Article
- Challenges for controlling bovine tuberculosis in South Africa.The Onderstepoort journal of veterinary research · 2020Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
Abstract
Cattle are the domestic animal reservoir for Mycobacterium bovis (M. bovis) which also affects other domestic animals, several wildlife species and humans leading to tuberculosis. The study area is in a resource-poor community that is surrounded by several game parks, where M. bovis infection has been previously diagnosed in wildlife. A cross-sectional study was carried out to determine the prevalence of M. bovis infection in 659 cattle from a total of 192 traditionally managed herds using the BOVIGAM® interferon gamma assay (IFN-γ). Infection was confirmed by post mortem examination and M. bovis isolation from three test-positive cattle. Genotyping of the M. bovis isolates was done using spoligotyping and VNTR (variable number of tandem repeats typing). The apparent M. bovis prevalence rate in cattle at animal level was 12% with a true population prevalence of 6% (95% Confidence interval (C.I) 3.8 to 8.1) and a herd prevalence of 28%. Spoligotyping analysis revealed that the M. bovis isolates belonged to spoligotype SB0130 and were shared with wildlife. Three VNTR profiles were identified among the SB0130 isolates from cattle, two of which had previously been detected in buffalo in a game reserve adjacent to the study area. The apparent widespread presence of M. bovis in the cattle population raises a serious public health concern and justifies further investigation into the risk factors for M. bovis transmission to cattle and humans. Moreover, there is an urgent need for effective bTB control measures to reduce infection in the communal cattle and prevent its spread to uninfected herds.
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Registered trials
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