Evidence map›Paper›PMID 31222471›Full record

ArticleThe Journal of membrane biology2019

Modulation of Transmembrane Domain Interactions in Neu Receptor Tyrosine Kinase by Membrane Fluidity and Cholesterol.

Muhammad Hasan, Dharmesh Patel, Natalie Ellis, Steven P Brown, Józef R Lewandowski, Ann M Dixon

Abstract read
PubMed Publisher
In one paragraph

Article in The Journal of membrane biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Special Issue: Membrane and Receptor Dynamics.The Journal of membrane biology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Muhammad HasanDepartment of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.
Dharmesh PatelDepartment of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.
Natalie EllisDepartment of Physics, University of Warwick, Coventry, CV4 7AL, UK.
Steven P BrownDepartment of Physics, University of Warwick, Coventry, CV4 7AL, UK.
Józef R LewandowskiDepartment of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.
Ann M DixonDepartment of Chemistry, University of Warwick, Coventry, CV4 7AL, UK. ann.dixon@warwick.ac.uk.ORCID 0000-0002-5261-304X
University of Warwick · GB

Funding

Biotechnology and Biological Sciences Research Council BB/D52700X/1Engineering and Physical Sciences Research Council EP/F500378/1
6 · The paper itself

Abstract

The activation mechanism of the ErbB family of receptors is of considerable medical interest as they are linked to a number of human cancers, including an aggressive form of breast cancer. In the rat analogue of the human ErbB2 receptor, referred to as Neu, a point mutation in the transmembrane domain (V

Indexed as

Membrane FluidityCholesterolErb-b2 Receptor Tyrosine KinasesHumansLipid BilayersNuclear Magnetic Resonance, BiomolecularProtein DomainsCholesterolERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesLipid BilayersCholesterol-recognitionMembrane bilayersNeu oncogeneReceptor tyrosine kinaseSolid-state NMR

Identifiers

PMID31222471
OpenAlexW2953382930

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.