Evidence map›Paper›PMID 31222186›Full record

ReviewNature reviews. Neuroscience2019

The diversity of GABAergic neurons and neural communication elements.

Z Josh Huang, Anirban Paul

Open access · greenAbstract readReview
In one paragraph

Review in Nature reviews. Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers.

0numbers the graph read from it
0cells of the map it votes in
126citing papers in PubMed
11.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

126 citing papers in PubMed, 232 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs-cAMP Signaling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Cell-type-resolvedbioRxiv : the preprint server for biology · 2025
    Article
  14. Article
  15. Article
  16. Neural Circuit Mapping and Neurotherapy-Based Strategies.Cellular and molecular neurobiology · 2025
    Review
  17. Article
  18. Article
  19. Article
  20. Understanding the molecular diversity of synapses.Nature reviews. Neuroscience · 2025
    Review

66 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Z Josh HuangCold Spring Harbor Laboratory, New York, NY, USA. huangj@cshl.edu.ORCID http://orcid.org/0000-0003-0592-028X
Anirban PaulCold Spring Harbor Laboratory, New York, NY, USA.ORCID http://orcid.org/0000-0001-5347-9260
Cold Spring Harbor Laboratory · USPennsylvania State University · US

Funding

Tool and Technology Development CoreU19MH114821 · NIMH · COLD SPRING HARBOR LABORATORY · PI HUANG, Z JOSH · 2017 to 2021
$64.5M
Transcriptome-based systematic discovery of GABAergic neurons in the neocortexR01MH109665 · NIMH · DUKE UNIVERSITY · PI HUANG, Z JOSH · 2016 to 2020
$4.0M
Genetic targeting of cortical pyramidal neuron subtypesR01MH101268 · NIMH · COLD SPRING HARBOR LABORATORY · PI ARLOTTA, PAOLA, HUANG, Z JOSH · 2013 to 2017
$3.9M
NIMH NIH HHS R01 MH101268NIMH NIH HHS R01 MH109665NIMH NIH HHS U19 MH114821
6 · The paper itself

Abstract

The phenotypic diversity of cortical GABAergic neurons is probably necessary for their functional versatility in shaping the spatiotemporal dynamics of neural circuit operations underlying cognition. Deciphering the logic of this diversity requires comprehensive analysis of multi-modal cell features and a framework of neuronal identity that reflects biological mechanisms and principles. Recent high-throughput single-cell analyses have generated unprecedented data sets characterizing the transcriptomes, morphology and electrophysiology of interneurons. We posit that cardinal interneuron types can be defined by their synaptic communication properties, which are encoded in key transcriptional signatures. This conceptual framework integrates multi-modal cell features, captures neuronal input-output properties fundamental to circuit operation and may advance understanding of the appropriate granularity of neuron types, towards a biologically grounded and operationally useful interneuron taxonomy.

Indexed as

AnimalsCell CommunicationCell DifferentiationGABAergic NeuronsHumansInterneuronsTranscriptome

Identifiers

PMID31222186
PMCPMC8796706
OpenAlexW2952995021

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.