Evidence map›Paper›PMID 31222124›Full record

ArticleScientific reports2019

Direct visualization of charge transport in suspended (or free-standing) DNA strands by low-energy electron microscopy.

Tatiana Latychevskaia, Conrad Escher, William Andregg, Michael Andregg, Hans-Werner Fink

Abstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  5. Article
  6. Synthesis and application of aRSC chemical biology · 2021
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tatiana LatychevskaiaPhysics Department, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland. tatiana@physik.uzh.ch.ORCID http://orcid.org/0000-0001-6693-8681
Conrad EscherPhysics Department, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
William AndreggHalcyon Molecular, 505 Penobscot Drive, Redwood City, CA, 94063, USA.
Michael AndreggHalcyon Molecular, 505 Penobscot Drive, Redwood City, CA, 94063, USA.
Hans-Werner FinkPhysics Department, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Low-energy electrons offer a unique possibility for long exposure imaging of individual biomolecules without significant radiation damage. In addition, low-energy electrons exhibit high sensitivity to local potentials and thus can be employed for imaging charges as small as a fraction of one elementary charge. The combination of these properties makes low-energy electrons an exciting tool for imaging charge transport in individual biomolecules. Here we demonstrate the imaging of individual deoxyribonucleic acid (DNA) molecules at the resolution of about 1 nm with simultaneous imaging of the charging of the DNA molecules that is of the order of less than one elementary charge per nanometer. The cross-correlation analysis performed on different sections of the DNA network reveals that the charge redistribution between the two regions is correlated. Thus, low-energy electron microscopy is capable to provide simultaneous imaging of macromolecular structure and its charge distribution which can be beneficial for imaging and constructing nano-bio-sensors.

Indexed as

DNAMicroscopy, ElectronNucleic Acid ConformationDNA

Identifiers

PMID31222124
PMCPMC6586886

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.