ArticleScientific reports2019
Structural Model of the ETR1 Ethylene Receptor Transmembrane Sensor Domain.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 49 citations in OpenAlex.
- Ethylene-regulated dimeric ETR1 kinase reveals multi-site EIN2 docking targeted by peptides that delay climacteric ripening.Science advances · 2026Article
- Rice ethylene receptors OsERS1/2 function as CaPlant communications · 2026Article
- Ethylene signaling and metabolite reprogramming in salt tolerance of Triticum aestivum.Scientific reports · 2026Article
- Integrative approaches for the structure-based functional understanding of the ethylene response in plants.The Plant journal : for cell and molecular biology · 2026Review
- POLARIS is a copper-binding peptide that interacts with ETR1 to negatively regulate ethylene signaling in Arabidopsis.Plant communications · 2025Article
- Molecular mechanism and structural models of protein-mediated copper transfer to the Arabidopsis thaliana ethylene receptor ETR1 at the ER membrane.Scientific reports · 2025Article
- Structural dynamics of the plant hormone receptor ETR1 in a native-like membrane environment.FEBS letters · 2025Article
- Modulation of plant growth and development through altered ethylene binding affinity of the ethylene receptor ETR1.BMC plant biology · 2025Article
- Validation ofJournal of fungi (Basel, Switzerland) · 2025Article
- Copper connections: coordinating transport, sensing and systemic signalling in plants.Quantitative plant biology · 2025Review
- Whole-Genome Sequencing and Analysis of Tumour-Forming Radish (International journal of molecular sciences · 2024Article
- Recent advances in understanding the regulation of plant secondary metabolite biosynthesis by ethylene-mediated pathways.Physiology and molecular biology of plants : an international journal of functional plant biology · 2024Review
- Crystallization of Ethylene Plant Hormone Receptor-Screening for Structure.Biomolecules · 2024Article
- Article
- Review
- Basis for high-affinity ethylene binding by the ethylene receptor ETR1 of Arabidopsis.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Roles of S-Adenosylmethionine and Its Derivatives in Salt Tolerance of Cotton.International journal of molecular sciences · 2023Review
- Loss of OPT3 function decreases phloem copper levels and impairs crosstalk between copper and iron homeostasis and shoot-to-root signaling in Arabidopsis thaliana.The Plant cell · 2023Article
- Spectroscopic and QM/MM studies of the Cu(I) binding site of the plant ethylene receptor ETR1.Biophysical journal · 2022Article
- Biophysical and pharmacokinetic characterization of a small-molecule inhibitor of RUNX1/ETO tetramerization with anti-leukemic effects.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The structure, mechanism of action and copper stoichiometry of the transmembrane sensor domain of the plant ethylene receptor ETR1 and homologs have remained elusive, hampering the understanding on how the perception of the plant hormone ethylene is transformed into a downstream signal. We generated the first structural model of the transmembrane sensor domain of ETR1 by integrating ab initio structure prediction and coevolutionary information. To refine and independently validate the model, we determined protein-related copper stoichiometries on purified receptor preparations and explored the helix arrangement by tryptophan scanning mutagenesis. All-atom molecular dynamics simulations of the dimeric model reveal how ethylene can bind proximal to the copper ions in the receptor, illustrating the initial stages of the ethylene perception process.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.