ArticleScientific reports2019
Microevolution of antimicrobial resistance and biofilm formation of Salmonella Typhimurium during persistence on pig farms.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Transmission of Salmonella clones between different animal species in a horse and cattle breeding region in Japan.Scientific reports · 2026Article
- Investigating Stress Tolerance of MultipleInternational journal of microbiology · 2026Article
- Integrating serotyping, MLST, and phenotypic data: decoding the evolutionary drivers ofApplied and environmental microbiology · 2025Article
- Article
- Temporal changes in fecal swine microbiome primarily reflectFrontiers in veterinary science · 2025Article
- Exploring the genetic landscape of the Copper Homeostasis and Silver Resistance Island (CHASRI) in Salmonella enterica.PloS one · 2025Article
- Sensitivity of dairy calfMicrobiology spectrum · 2024Article
- Genomic insights of Salmonella isolated from dry fermented sausage production chains in Spain and France.Scientific reports · 2024Article
- SIMBA Method-Simultaneous Detection of Antimicrobial and Anti-biofilm Activity of New Compounds UsingBio-protocol · 2023Article
- Testable Candidate Immune Correlates of Protection for Porcine Reproductive and Respiratory Syndrome Virus Vaccination.Vaccines · 2023Review
- Increased Multidrug-Resistant Salmonella enterica I Serotype 4,[5],12:i:- Infections Associated with Pork, United States, 2009-2018.Emerging infectious diseases · 2023Article
- Genomic alterations involved in fluoroquinolone resistance development in Staphylococcus aureus.PloS one · 2023Article
- Review
- Salmonella Derby from pig production chain over a 10-year period: antimicrobial resistance, biofilm formation, and genetic relatedness.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Article
- Multidrug-Resistant Biofilms (MDR): Main Mechanisms of Tolerance and Resistance in the Food Supply Chain.Pathogens (Basel, Switzerland) · 2022Review
- Development of a Phage Cocktail to TargetPharmaceuticals (Basel, Switzerland) · 2022Article
- Effect of pH and Salinity on the Ability ofFrontiers in microbiology · 2022Article
- Overcoming reduced antibiotic susceptibility in intracellular Salmonella enterica serovar Typhimurium using AR-12.FEMS microbiology letters · 2021Article
- Role played by the environment in the emergence and spread of antimicrobial resistance (AMR) through the food chain.EFSA journal. European Food Safety Authority · 2021Article
- Ecological niche adaptation of Salmonella Typhimurium U288 is associated with altered pathogenicity and reduced zoonotic potential.Communications biology · 2021Article
Corrections and comments
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Authors and funding
8 authors.
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Abstract
Salmonella Typhimurium and its monophasic variant S. 4,[5],12:i:- are the dominant serotypes associated with pigs in many countries. We investigated their population structure on nine farms using whole genome sequencing, and their genotypic and phenotypic variation. The population structure revealed the presence of phylogenetically distinct clades consisting of closely related clones of S. Typhimurium or S. 4,[5],12:i:- on each pig farm, that persisted between production cycles. All the S. 4,[5],12:i:- strains carried the Salmonella genomic island-4 (SGI-4), which confers resistance to heavy metals, and half of the strains contained the mTmV prophage, harbouring the sopE virulence gene. Most clonal groups were highly drug resistant due to the presence of multiple antimicrobial resistance (AMR) genes, and two clades exhibited evidence of recent on-farm plasmid-mediated acquisition of additional AMR genes, including an IncHI2 plasmid. Biofilm formation was highly variable but had a strong phylogenetic signature. Strains capable of forming biofilm with the greatest biomass were from the S. 4,[5],12:i:- and S. Typhimurium DT104 clades, the two dominant pandemic clones found over the last 25 years. On-farm microevolution resulted in enhanced biofilm formation in subsequent production cycle.
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