ArticleScientific reports2019
Quantitative analysis of the macula with optical coherence tomography angiography in normal Japanese subjects: The Taiwa Study.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 33 citations in OpenAlex.
- Plasma Glial Fibrillary Acidic Protein and Neurofilament Light Chain Concentrations Are Inversely Associated with Retinal Microvascular Perfusion and Vessel Density in Cognitively Normal Individuals with Familial or Genetic Risk Factors for Alzheimer's Disease.Diagnostics (Basel, Switzerland) · 2026Article
- Diabetes May Modulate the Association Between Age and Optical Coherence Tomography Angiography Parameters: A Serial, Cross-Sectional Study.Journal of personalized medicine · 2026Article
- Parameters associated with the size of the foveal avascular zone in healthy elderly eyes.Scientific reports · 2026Article
- Reduced plasma oxytocin levels in patients with open-angle glaucoma.Japanese journal of ophthalmology · 2026Article
- Automated FAZ segmentation and diabetic retinopathy classification using OCTA images.BMC ophthalmology · 2025Article
- Preferential Sites of Retinal Capillary Occlusion in Sickle Cell Disease.Investigative ophthalmology & visual science · 2025Article
- Fundus blood flow density changes in the smoking population by artificial intelligence-based optical coherence tomography angiography.International journal of ophthalmology · 2025Article
- Retinal capillary density among healthy Egyptian and South Asian students: an optical coherence tomography angiography study.International journal of ophthalmology · 2025Article
- The central retina vessel density and foveal avascular zone values of 792 healthy adults using optical coherence tomography angiography.Eye (London, England) · 2024Article
- Association of Male Sex and Microvascular Alterations on Optical Coherence Tomography Angiography in Diabetes.Translational vision science & technology · 2023Article
- OCTA biomarkers in adults aged 50 and above: a prospective and cross-sectional community-based study.BMC ophthalmology · 2023Article
- Age- and sex-related differences in the retinal capillary plexus in healthy Chinese adults.Eye and vision (London, England) · 2022Article
- Age-related assessment of foveal avascular zone and surrounding capillary networks with swept source optical coherence tomography angiography in healthy eyes.Eye (London, England) · 2022Observational
- Normative data on the foveal avascular zone in a young healthy Irish population using optical coherence tomography angiography.European journal of ophthalmology · 2022Article
- Assessment of relationship between retinal perfusion and retina thickness in healthy children and adolescents.PloS one · 2022Article
- Macular Retinal Microvasculature of Hyperopia, Emmetropia, and Myopia in Children.Frontiers in medicine · 2022Article
- The foveal avascular zone area in healthy eyes measured by ocular coherence tomography angiography using a full spectrum probabilistic algorithm.International ophthalmology · 2021Article
- Associations Between Capillary Diameter, Capillary Density, and Microaneurysms in Diabetic Retinopathy: A High-Resolution Confocal Microscopy Study.Translational vision science & technology · 2021Article
- Quantitative Analysis of the Macular and Peripapillary Capillary Network with Optical Coherence Tomography Angiography in Chinese Adolescents: The Tuyou County Pediatric Eye (TYPE) Study.International journal of general medicine · 2021Article
- Retinal Microcirculation as a Correlate of a Systemic Capillary Impairment After Severe Acute Respiratory Syndrome Coronavirus 2 Infection.Frontiers in medicine · 2021Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
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Abstract
This study evaluated age-related changes in the superficial and deep retinal capillary plexus (SCP and DCP, respectively) and in the foveal avascular zone (FAZ). SCP and DCP perfusion density (PD) were measured in optical coherence tomography angiography (OCTA) macular scans of 145 eyes of 145 healthy Japanese subjects, and findings were compared with SCP FAZ and clinical data. We found that age was negatively correlated with SCP and DCP PD (r = -0.17, P = 0.04 and r = -0.20, P = 0.02, respectively) and positively correlated with FAZ area (r = 0.18, P = 0.03). SCP and DCP PD were correlated with each other (r = 0.67, P < 0.001). FAZ area was negatively correlated with SCP PD, DCP PD and central macular thickness (CMT) (r = -0.18, P = 0.03; r = -0.25, P < 0.01; and r = -0.39, P < 0.001, respectively). FAZ was larger and CMT was lower (P = 0.01 and P < 0.001, respectively) in women than men. SCP and DCP PD were positively correlated with estimated glomerular filtration rate (r = 0.17, P = 0.03 and r = 0.24, P < 0.01, respectively). Multiple regression analysis confirmed that age independently affected DCP PD and FAZ (P = 0.02 and P < 0.01, respectively) and that CMT independently affected FAZ area (P < 0.001). Thus, normal subjects showed age-related decreases in macular PD and renal function. FAZ and CMT were related, suggesting that age-related changes in macular thickness also affect capillary vasculature.
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