Evidence map›Paper›PMID 31221856›Full record

ArticleScience (New York, N.Y.)2019

Direct arene C-H fluorination with

Wei Chen, Zeng Huang, Nicholas E S Tay, Benjamin Giglio, Mengzhe Wang, Hui Wang, Zhanhong Wu, David A Nicewicz, Zibo Li

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed.

  1. Article
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  5. Article
  6. Review
  7. Article
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  9. Article
  10. Article
  11. Article
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  14. Review
  15. Article
  16. Review
  17. Article
  18. Radical Polarity.Journal of the American Chemical Society · 2024
    Article
  19. C-H Labeling with [ACS central science · 2024
    Review
  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wei Chen *Biomedical Research Imaging Center, Department of Radiology, and UNC Lineberger Comprehensive Cancer Center, University of North Carolina-Chapel Hill, Chapel Hill, NC 27514, USA.ORCID 0000-0002-3694-5204
Zeng Huang *Biomedical Research Imaging Center, Department of Radiology, and UNC Lineberger Comprehensive Cancer Center, University of North Carolina-Chapel Hill, Chapel Hill, NC 27514, USA.ORCID 0000-0001-5796-3631
Nicholas E S Tay *Department of Chemistry, University of North Carolina-Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0002-4063-8880
Benjamin GiglioBiomedical Research Imaging Center, Department of Radiology, and UNC Lineberger Comprehensive Cancer Center, University of North Carolina-Chapel Hill, Chapel Hill, NC 27514, USA.
Mengzhe WangBiomedical Research Imaging Center, Department of Radiology, and UNC Lineberger Comprehensive Cancer Center, University of North Carolina-Chapel Hill, Chapel Hill, NC 27514, USA.
Hui WangBiomedical Research Imaging Center, Department of Radiology, and UNC Lineberger Comprehensive Cancer Center, University of North Carolina-Chapel Hill, Chapel Hill, NC 27514, USA.ORCID 0000-0002-2346-8621
Zhanhong WuBiomedical Research Imaging Center, Department of Radiology, and UNC Lineberger Comprehensive Cancer Center, University of North Carolina-Chapel Hill, Chapel Hill, NC 27514, USA.ORCID 0000-0002-3528-5603
David A NicewiczDepartment of Chemistry, University of North Carolina-Chapel Hill, Chapel Hill, NC 27599, USA. nicewicz@unc.edu ziboli@med.unc.edu.ORCID 0000-0003-1199-9879
Zibo LiBiomedical Research Imaging Center, Department of Radiology, and UNC Lineberger Comprehensive Cancer Center, University of North Carolina-Chapel Hill, Chapel Hill, NC 27514, USA. nicewicz@unc.edu ziboli@med.unc.edu.ORCID 0000-0002-1063-0298

Funding

The Tetrazine Ligation for Efficient 18F Labeling and Pretargeted Imaging/Radiotherapy of CancerR01EB014354 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FOX, JOSEPH M, LI, ZIBO · 2013 to 2016
$1.4M
Catalytic Methods for Rapid Aromatic DerivatizationR01GM120186 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NICEWICZ, DAVID A · 2016 to 2019
$1.1M
Small Animal PET/CT for Preclinical Imaging ResearchS10OD023611 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, ZIBO · 2017 to 2017
$835k
NIBIB NIH HHS R01 EB014354NIGMS NIH HHS R01 GM120186NIH HHS S10 OD023611ODCDC CDC HHS S10 OD023611
6 · The paper itself

Abstract

Positron emission tomography (PET) plays key roles in drug discovery and development, as well as medical imaging. However, there is a dearth of efficient and simple radiolabeling methods for aromatic C-H bonds, which limits advancements in PET radiotracer development. Here, we disclose a mild method for the fluorine-18 (

Identifiers

PMID31221856
PMCPMC6680023

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.